Development and Characterisation of Polymeric Nanacapsules Containing Macromolecule

Abu Abed, O. S., Elkordy, Amal, Chaw, Cheng, Williams, Lee and Carlile, Mark (2016) Development and Characterisation of Polymeric Nanacapsules Containing Macromolecule. Molecular Therapy, 24 (Supp 1). S237-S238. ISSN 1525-0016

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Abstract

Oral drug delivery systems are the most common route of administration. However,
development oral delivery system containing macromolecules is still challenging due to
different hurdles, including, digestive enzymes degradation and physiochemical
properties of the molecules. Currently, several techniques have been applied to deliver
the macromolecules orally e.g. polymer conjugates, excipients such as cyclodextrin, and
entrapment inside carriers, such as liposomes, and nanocapsule systems. Accordingly, the
aim of this study is to overcome these challenges by encapsulating macromolecule inside
polymeric nanocapsules, trypsin as a protein was used as a model macromolecule.

Item Type: Article
Subjects: Sciences > Pharmacy and Pharmacology
Divisions: Faculty of Health Sciences and Wellbeing
Depositing User: Amal Elkordy
Date Deposited: 11 May 2016 08:04
Last Modified: 20 May 2019 11:34
URI: http://sure.sunderland.ac.uk/id/eprint/6307

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