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The introduction of the Cancer Research UK Stratified Medicine Programme 2 (CRUK SMP2) in North East England; lessons learned and experience gained

Greystoke, A, Hogarth, L, Patterson, M, Williams, I, Ness, T, Georgiadis, K, Bolt, L, Bettison, I, Turner, D, Jamieson, D, Simmons, T, Hughes, A, Jaedicke, Katrin, Gardiner, J, Mulvenna, P, Leaning, D, Bradshaw, A, Butler, R and Black, F (2016) The introduction of the Cancer Research UK Stratified Medicine Programme 2 (CRUK SMP2) in North East England; lessons learned and experience gained. Lung Cancer, 91. S20. ISSN 0169-5002

Item Type: Article


Introduction: The CRUK SMP2 programme was set-up to evaluate
the feasibility of performing large scale molecular analysis within the
NHS on the (often small) diagnostic biopsies obtained in NSCLC. The
results are used to allocate patients to an appropriate molecular therapy
within the “umbrella” MATRIX trial. Newcastle opened SMP2 on
01/10/2014. Here we report our first year’s experience.
Methods: NSCLC patients with PS 0–2 were consented onto the CRUK
SMP2. Matched residual diagnostic tissue and blood were sent to All
Wales Genetics Laboratory, Cardiff. Samples with >70ng DNA were
assessed for 28 oncogenes using Next Genuine Sequencing on the Illumina
SMP2 panel.
Results: 116 patients were consented from 6/10/14–1/10/15 referred
from 12 oncologists. The data on patient/sample flow is shown in Fig
1. Median survival was 161 days from consent. The 1st sample was
sent to Cardiff on 28/1/15 as the Illumina panel was undergoing fi-
nal validation. 50 samples have been sent; 11 had insufficient DNA;
these samples had lower cell number (but with no impact of necrosis/tumour
proportion); The most commonly altered gene was K-Ras
(13 of 22 adenocarcinomas). Only 2 patients with results from >25
of the 28 genes had no tier 1 or 2 ie potentially treatable molecular
abnormalities. The median time from consent to result was 109 days
(range 45–250) with delays occurring throughout the pathway.
Conclusion: Patients and oncologists are keen to be involved in
molecular profiling; but patients need to be consented early to allow
results to guide therapy. Prioritisation of samples is key. Not all
samples are suitable for analysis due to small cell number or low tumour
proportion. Molecular analysis may require extra resource in
pathology, if it is to become standard of care. The first 4 patients to
start treatment on MATRIX were enrolled from 27/8/15 in Newcastle.
Disclosure: All authors have declared no conflicts of interest.

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Depositing User: Katrin Jaedicke


Item ID: 9596
Identification Number:
ISSN: 0169-5002
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Users with ORCIDS

ORCID for Katrin Jaedicke: ORCID iD

Catalogue record

Date Deposited: 06 Jun 2018 12:17
Last Modified: 18 Dec 2019 16:06


Author: Katrin Jaedicke ORCID iD
Author: A Greystoke
Author: L Hogarth
Author: M Patterson
Author: I Williams
Author: T Ness
Author: K Georgiadis
Author: L Bolt
Author: I Bettison
Author: D Turner
Author: D Jamieson
Author: T Simmons
Author: A Hughes
Author: J Gardiner
Author: P Mulvenna
Author: D Leaning
Author: A Bradshaw
Author: R Butler
Author: F Black

University Divisions

Faculty of Health Sciences and Wellbeing
Faculty of Health Sciences and Wellbeing > School of Nursing and Health Sciences


Sciences > Biomedical Sciences
Sciences > Health Sciences

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