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Dietary intervention modifies DNA methylation age assessed by the epigenetic clock

Sae-Lee, Chanachai, Corsi, Sarah, Barrow, Timothy, Kunhle, Gunter, Bollati, Valentina, Mathers, John and Byun, Hyang-Min (2018) Dietary intervention modifies DNA methylation age assessed by the epigenetic clock. Molecular Nutrition & Food Research, 62 (23). ISSN 1613-4133 (Electronic)

Item Type: Article


Scope: Alterations in DNA methylation patterns are correlated with aging, environmental exposures and disease pathophysiology; the possibility of reverting or preventing these processes through dietary intervention is gaining momentum. In particular, methyl donors that provide S-adenosyl-methionine for one-carbon metabolism and polyphenols such as flavanols that inhibit the activity of DNA methyltransferases (DNMTs) could be key modifiers of epigenetic patterns.
Methods and results: We assessed DNA methylation patterns in publicly available Illumina Infinium 450K methylation datasets from intervention studies with either folic acid + vitamin B12 (GSE74548) or monomeric and oligomeric flavanols (MOF) (GSE54690) in 44 and 13 participants, respectively. Global DNA methylation levels increased in unmethylated regions such as CpG islands and shores following folic acid + vitamin B12 supplementation and decreased in highly methylated regions, including shelves and open-seas following intervention with MOF. After supplementation with folic acid + vitamin B12, epigenetic age, estimated by the Horvath ‘epigenetic clock’ model, was reduced in women with the MTHFR 677CC genotype.
Conclusions: The effects of supplementation with folic acid + vitamin B12 and MOF on DNA methylation age are dependent upon gender and MTHFR genotype. Additionally, our findings demonstrate the potential for these dietary factors to modulate global DNA methylation profiles.

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Depositing User: Timothy Barrow


Item ID: 9997
Identification Number:
ISSN: 1613-4133 (Electronic)
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ORCID for Timothy Barrow: ORCID iD

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Date Deposited: 01 Oct 2018 08:28
Last Modified: 30 Sep 2020 10:48


Author: Timothy Barrow ORCID iD
Author: Chanachai Sae-Lee
Author: Sarah Corsi
Author: Gunter Kunhle
Author: Valentina Bollati
Author: John Mathers
Author: Hyang-Min Byun

University Divisions

Faculty of Health Sciences and Wellbeing
Faculty of Health Sciences and Wellbeing > School of Nursing and Health Sciences


Sciences > Biomedical Sciences
Sciences > Health Sciences

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