Jane Armstrong

Senior Lecturer

Health Sciences& W-b (F) - Nursing & Health Sci (S)

University of Sunderland

Cell signalling (autophagy and apoptosis), Skin biology and development of 3D skin equivalent models, Skin cancer – Melanoma, Psoriasis, Biomarker identification, Retinoid biology and development of retinoic acid metabolism blocking agents for therapy

Dr Jane Armstrong is a Senior Lecturer in Life Sciences in the Department of Pharmacy, Health and Well-being. The catabolic process of autophagy (self-eating) promotes cell survival and cell health by removing damaged proteins and organelles and providing energy. Deregulated autophagy is now associated with numerous diseases, including cancer. Her current research is directed towards deciphering the molecular regulation of autophagy in the skin, in the context of skin cancer (primarily melanoma) and the inflammatory skin disorder psoriasis. The identification of novel regulators of autophagy will ultimately facilitate the discovery of novel therapeutic targets and biomarkers of disease progression. She also has an interest in retinoid biology and pharmacology involving study into the memore...

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Latest Additions

  1. Flockhart, R, Armstrong, Jane, Reynolds, NJ and Lovat, PE (2009) NFAT signalling is a novel target of oncogenic BRAF in metastatic melanoma. British Journal of Cancer, 101 (8). pp. 1448-1455. ISSN 0007-0920
  2. O'Boyle, Graeme, Swidenbank, I, Marshall, H, Barker, CE, Armstrong, Jane, White, SA, Fricker, SP, Plummer, R, Wright, M and Lovat, PE (2013) Inhibition of CXCR4-CXCL12 chemotaxis in melanoma by AMD11070. British Journal of Cancer, 108. pp. 1634-1640. ISSN 0007-0920
  3. Armstrong, Jane, Martin, S, Illingworth, N A, Jamieson, D, Neilson, A, Lovat, PE, Redfern, CPF and Veal, GJ (2011) The impact of retinoic acid treatment on the sensitivity of neuroblastoma cells to fenretinide. Oncology Reports, 27. pp. 293-298. ISSN 1791-2431
  4. McKee, Christopher S, Hill, David S, Redfern, Christopher PF, Armstrong, Jane and Lovat, Penny E (2013) Oncogenic BRAF signalling increases Mcl-1 expression in cutaneous metastatic melanoma. Experimental Dermatology, 22 (11). pp. 767-769. ISSN 1600-0625
  5. Hernandez-Tiedra, Sonia, Fabrias, Gemma, Davila, David, Salanueva, Inigo J, Casas, Josefina, Montes, L Ruth, Anton, Zurine, Garcia-Taboada, Elena, Salazar-Roa, Maria, Lorente, Mar, Nylandsted, Jesper, Armstrong, Jane, Lopez-Valero, Israel, McKee, Christopher, Serrano-Puebla, Ana, Garcia-Lopez, Roberto, Gonzalez-Martinez, Jose, Abad, Jose L, Hanada, Kentaro, Boya, Patricia, Goni, Felix M, Guzman, Manuel, Lovat, Penny, Jaattela, Marja, Alonso, Alicia and Velasco, Guillermo (2016) Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization. Autophagy, 12 (11). pp. 2213-2229. ISSN 1554-8627