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Prospective Assessment of the Diagnostic Accuracy of Multi-site Photoplethysmography Pulse Measurements for Diagnosis of Peripheral Artery Disease in Primary Care.

Stansby, Gerard, Sims, Andrew J, Wilson, Lesley, Beale, Tom A W, Wightman, James, Guri, Ina, Wilkes, Scott, Haining, Shona and Allen, John (2022) Prospective Assessment of the Diagnostic Accuracy of Multi-site Photoplethysmography Pulse Measurements for Diagnosis of Peripheral Artery Disease in Primary Care. Angiology, 74 (9). pp. 211-867. ISSN 1940-1574

Item Type: Article

Abstract

Peripheral arterial disease (PAD) is associated with cerebral and coronary artery disease. Symptomatic PAD affects about 5% of people over 55 years; many more have asymptomatic PAD. Early detection enables modification of arterial disease risk factors. Diagnostically, assessment of symptoms or signs can be unreliable; ankle brachial pressure index (ABPI) testing is time-consuming and few healthcare professionals are properly trained. This study assessed the diagnostic accuracy of multi-site photoplethysmography (MPPG), an alternative non-invasive test for PAD, in primary care. PAD patients identified from general practice registers were age- and sex-matched with controls. Participants were assessed using MPPG, ABPI and duplex ultrasound (DUS). Outcome measures were sensitivity and specificity of MPPG and ABPI (relative to DUS) and concordance. MPPG test results were available in 249 of 298 eligible participants from 16 practices between May 2015 and November 2016. DUS detected PAD in 101/249 (40.6%). MPPG sensitivity was 79.8% (95% confidence interval [CI] 69.9-87.6%), with specificity 71.9% (95% CI 63.7-79.2%). ABPI sensitivity was 80.2% (95% CI 70.8-87.6%), with specificity 88.6% (95% CI 82-93.5%). With comparable sensitivity to ABPI, MPPG is quick, automated and simpler to do than ABPI; it offers the potential for rapid and accessible PAD assessments in primary care.

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Depositing User: Scott Wilkes

Identifiers

Item ID: 17533
Identification Number: https://doi.org/10.1177/00033197221121614
ISSN: 1940-1574
URI: http://sure.sunderland.ac.uk/id/eprint/17533
Official URL: https://journals.sagepub.com/doi/abs/10.1177/00033...

Users with ORCIDS

ORCID for Scott Wilkes: ORCID iD orcid.org/0000-0003-2949-7711

Catalogue record

Date Deposited: 08 Apr 2024 10:14
Last Modified: 08 Apr 2024 10:14

Contributors

Author: Scott Wilkes ORCID iD
Author: Gerard Stansby
Author: Andrew J Sims
Author: Lesley Wilson
Author: Tom A W Beale
Author: James Wightman
Author: Ina Guri
Author: Shona Haining
Author: John Allen

University Divisions

Faculty of Health Sciences and Wellbeing > School of Medicine

Subjects

Sciences > Health Sciences
Sciences

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