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MK-801 increases the baseline level of anxiety in mice introduced to a spatial memory task without prior habituation.

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Ennaceur, Abdelkader, Michalikova, Simona, van Rensburg, Ruan and Chazot, P L (2011) MK-801 increases the baseline level of anxiety in mice introduced to a spatial memory task without prior habituation. Neuropharmacology, 61 (5-6). pp. 981-91. ISSN 0028-3908

Item Type: Article

Abstract

c57BL/6J mice were introduced to a nine arm radial maze without prior habituation and trained in the acquisition of a working memory task in 16 sessions, one session per day. In this maze mice need to climb onto an upward inclined bridge in order to reach and cross onto an arm. They received in each session an i.p. injection of MK-801 (0.1 mg/kg) 30 min before training or immediately after training. MK-801 pretreated mice made significantly more entries onto the bridges, fewer entries onto the arms and took significantly longer time to make a first arm visit compared to saline and MK-801 post-treated mice during the first 3 session blocks (4 sessions per block). These results indicate that MK-801 induced anxiety which was extended throughout the first 3 session blocks. MK-801 pre-treated mice made also significantly more errors and required more sessions to reach the criterion compared to saline and MK-801 post-treated mice. Administration of MK-801 after training did not affect the acquisition of the task. The present results indicate that MK-801 pre-treatment impaired the acquisition of a spatial task and this can be accounted for by its effect on the baseline level of anxiety which was elevated. The introduction of mice to the acquisition of the task without prior habituation demonstrates that a drug treatment can affect learning and memory by increasing and/or prolonging anxiety. Such effect may be confounded with learning and memory performance and not detected with pre-habituation training procedures, particularly when the number of sessions is determined a-priori.

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More Information

Depositing User: Abdelkader Ennaceur

Identifiers

Item ID: 2718
Identification Number: https://doi.org/10.1016/j.neuropharm.2011.06.027
ISSN: 0028-3908
URI: http://sure.sunderland.ac.uk/id/eprint/2718
Official URL: http://www.sciencedirect.com/science/journal/00283...

Users with ORCIDS

ORCID for Abdelkader Ennaceur: ORCID iD orcid.org/0000-0001-6398-4383

Catalogue record

Date Deposited: 22 Feb 2012 12:34
Last Modified: 18 Dec 2019 15:33

Contributors

Author: Abdelkader Ennaceur ORCID iD
Author: Simona Michalikova
Author: Ruan van Rensburg
Author: P L Chazot

University Divisions

Faculty of Health Sciences and Wellbeing
Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences

Subjects

Sciences > Biomedical Sciences
Sciences > Health Sciences
Sciences > Pharmacy and Pharmacology

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  • MK-801 increases the baseline level of anxiety in mice introduced to a spatial memory task without prior habituation. (deposited 22 Feb 2012 12:34) [Currently Displayed]