A new one-trial test for neurobiological studies of memory in rats. III. Spatial vs. non-spatial working memory

Ennaceur, Abdelkader and Meliani, Kamel (1992) A new one-trial test for neurobiological studies of memory in rats. III. Spatial vs. non-spatial working memory. Behav Brain Res., 51 (1). pp. 83-92. ISSN 0166-4328

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Abstract

Rats were submitted to object and spatial recognition tests (both based on the same paradigm) and to the radial-arm maze. The results are as follows: (1) rats could discriminate between a new and a familiar object when the retention delay was 1 min, 15 min or 60 min but not 24h. The relationship between the level of discrimination and intertrial delays is quadratic with a maximum for 15 min. (2) Exposure to distractive stimuli during the retention delay may impair object recognition. (3) Rats discriminated between a new and a familiar space. (4) There is no correlation between the three tests which argues for a multiple form of working memory, especially a spatial and a non-spatial one. (5) Medial septal lesion did not impair object and spatial recognition memory, but the level of discrimination in the spatial recognition test was significantly reduced compared to that of control.

Item Type: Article
Subjects: Sciences > Biomedical Sciences
Psychology > Cognitive Behaviour
Psychology > Neuropsychology
Sciences > Pharmacy and Pharmacology
Psychology > Psychology
Divisions: Faculty of Health Sciences and Wellbeing
Faculty of Applied Sciences > Department of Pharmacy Health and Wellbeing
Health Sciences and Wellbeing Beacon > Drug Discovery and Application Workstream
Related URLs:
Depositing User: Abdelkader Ennaceur
Date Deposited: 23 Aug 2017 07:51
Last Modified: 19 Sep 2017 16:31
URI: http://sure.sunderland.ac.uk/id/eprint/7658

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