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The Effects of Hydration Parameters and Co-Surfactants on Methylene Blue-Loaded Niosomes Prepared by the Thin Film Hydration Method

Yeo, Li Key, Chaw, Cheng and Elkordy, Amal (2019) The Effects of Hydration Parameters and Co-Surfactants on Methylene Blue-Loaded Niosomes Prepared by the Thin Film Hydration Method. Pharmaceuticals, 12(2) (46).

Item Type: Article

Abstract

Abstract: This work aimed to investigate and optimise the effects of co-surfactants, hydration volume, and time on the entrapment of methylene blue (MB) within niosomes and the vesicle sizes of MB-loaded niosomes upon different storage temperatures. Niosomes were prepared by the thin film hydration method followed by gel permeation chromatography to obtain purified niosome suspensions. The probe sonication method was used to reduce the niosome vesicle size and distribution. Highest entrapment efficiencies (%EE) were determined for niosomal formulations containing Span® 60, cholesterol, and Cremophor® ELP (E2 and E3), which were prepared with a hydration volume of 5 mL. The hydration time was 15 min for E2 and 60 min for E3 (%EE = 40.1 ± 7.9% and 32.9 ± 10.1% for E3 and E2, respectively). The final lipid contents in the formulations were shown to have an impact on %EE.

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More Information

Depositing User: Amal Elkordy

Identifiers

Item ID: 10633
Identification Number: https://doi.org/10.3390/ph12020046
URI: http://sure.sunderland.ac.uk/id/eprint/10633
Official URL: https://www.mdpi.com/1424-8247/12/2/46/htm

Users with ORCIDS

ORCID for Cheng Chaw: ORCID iD orcid.org/0000-0002-7450-4100
ORCID for Amal Elkordy: ORCID iD orcid.org/0000-0002-0781-1127

Catalogue record

Date Deposited: 29 Mar 2019 12:25
Last Modified: 16 May 2022 13:01

Contributors

Author: Cheng Chaw ORCID iD
Author: Amal Elkordy ORCID iD
Author: Li Key Yeo

University Divisions

Faculty of Health Sciences and Wellbeing
Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences

Subjects

Sciences > Pharmacy and Pharmacology

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