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GABA Regulation of Burst Firing in Hippocampal Astrocyte Neural Circuit: A Biophysical Model

Liu, Junxiu, McDaid, Liam, Araque, Alfonso, Wade, John, Harkin, Jim, Karim, Shvan, Henshall, David C., Connolly, Niamh M. C., Johnson, Anju P., Tyrrell, Andy M., Timmis, Jonathan, Millard, Alan G., Hilder, James and Halliday, David M. (2019) GABA Regulation of Burst Firing in Hippocampal Astrocyte Neural Circuit: A Biophysical Model. Frontiers in Cellular Neuroscience, 13. p. 335. ISSN 1662-5102

Item Type: Article

Abstract

It is now widely accepted that glia cells and gamma-aminobutyric acidergic (GABA) interneurons dynamically regulate synaptic transmission and neuronal activity in time and space. This paper presents a biophysical model that captures the interaction between an astrocyte cell, a GABA interneuron and pre/postsynaptic neurons. Specifically, GABA released from a GABA interneuron triggers in astrocytes the release of calcium (Ca<sup>2+</sup>) from the endoplasmic reticulum via the inositol 1, 4, 5-trisphosphate (IP<sub>3</sub>) pathway. This results in gliotransmission which elevates the presynaptic transmission probability rate (PR) causing weight potentiation and a gradual increase in postsynaptic neuronal firing, that eventually stabilizes. However, by capturing the complex interactions between IP<sub>3</sub>, generated from both GABA and the 2-arachidonyl glycerol (2-AG) pathway, and PR, this paper shows that this interaction not only gives rise to an initial weight potentiation phase but also this phase is followed by postsynaptic bursting behavior. Moreover, the model will show that there is a presynaptic frequency range over which burst firing can occur. The proposed model offers a novel cellular level mechanism that may underpin both seizure-like activity and neuronal synchrony across different brain regions.

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Depositing User: Jonathan Timmis

Identifiers

Item ID: 11851
Identification Number: https://doi.org/10.3389/fncel.2019.00335
ISSN: 1662-5102
URI: http://sure.sunderland.ac.uk/id/eprint/11851
Official URL: https://www.frontiersin.org/article/10.3389/fncel....

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Catalogue record

Date Deposited: 24 Mar 2020 14:02
Last Modified: 30 Sep 2020 10:50

Contributors

Author: Junxiu Liu
Author: Liam McDaid
Author: Alfonso Araque
Author: John Wade
Author: Jim Harkin
Author: Shvan Karim
Author: David C. Henshall
Author: Niamh M. C. Connolly
Author: Anju P. Johnson
Author: Andy M. Tyrrell
Author: Jonathan Timmis
Author: Alan G. Millard
Author: James Hilder
Author: David M. Halliday

University Divisions

Faculty of Technology > School of Computer Science

Subjects

Computing > Artificial Intelligence
Sciences > Biomedical Sciences

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