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Environmental Epitranscriptomics

Cayir, Akin, Byun, Hyang-Min and Barrow, Timothy (2020) Environmental Epitranscriptomics. Environmental Research. p. 109885. ISSN 0013-9351

Item Type: Article

Abstract

Chemical modifications of RNA molecules have gained increasing attention since evidence emerged for their substantive roles in a range of biological processes, such as the stability and translation of mRNA transcripts. More than 150 modifications have been identified in different organisms to date, collectively known as the ‘epitranscriptome’, with 6-methyladenosine (m6A), 5-methylcytidine (m5C), pseudouridine and N1-methyladenosine (m1A) the most extensively investigated. Although we are just beginning to elucidate the roles of these modifications in cellular functions, there is already evidence for their dysregulation in diseases such as cancer and neurodevelopmental disorders. There is currently more limited knowledge regarding how environmental exposures affect the epitranscriptome and how this may mediate disease risk, but evidence is beginning to emerge. Here, we review the current evidence for the impact of environmental exposures such as benzo[a]pyrene, bisphenol A, pesticides, metals and nanoparticles upon RNA modifications and the expression of their ‘writers’ (methyl transferases), ‘erasers’ (demethylases) and ‘readers’. We discuss future directions of the field and identify areas of particular promise and consider the technical challenges that are faced.

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Additional Information: ** Article version: AM ** Embargo end date: 31-12-9999 ** From Elsevier via Jisc Publications Router ** History: accepted 28-06-2020; issue date 11-07-2020. ** Licence for AM version of this article: This article is under embargo with an end date yet to be finalised.
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Identifiers

Item ID: 12211
Identification Number: https://doi.org/10.1016/j.envres.2020.109885
ISSN: 0013-9351
URI: http://sure.sunderland.ac.uk/id/eprint/12211
Official URL: https://www.sciencedirect.com/science/article/pii/...

Users with ORCIDS

ORCID for Timothy Barrow: ORCID iD orcid.org/0000-0003-4551-3857

Catalogue record

Date Deposited: 14 Jul 2020 10:39
Last Modified: 28 Jun 2021 02:38

Contributors

Author: Timothy Barrow ORCID iD
Author: Akin Cayir
Author: Hyang-Min Byun

University Divisions

Faculty of Health Sciences and Wellbeing > School of Nursing and Health Sciences

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