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Marked for death.

Petrie, Kevin and Zelent, Arthur (2008) Marked for death. Nature cell biology, 10 (5). pp. 507-9. ISSN 1476-4679

Item Type: Article

Abstract

SUMOylation of PML–RARα oncoprotein has been linked to its arsenic-induced degradation and the therapeutic response in acute promyelocytic leukaemia. Two groups identify PML as an in vivo target of the RING finger ubiquitin E3 ligase RNF4, which specifically binds polySUMOylated PML and is essential for the arsenic-induced catabolism of both PML and PML–RARα.

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More Information

Depositing User: Kevin Petrie

Identifiers

Item ID: 12430
Identification Number: https://doi.org/10.1038/ncb0508-507
ISSN: 1476-4679
URI: http://sure.sunderland.ac.uk/id/eprint/12430
Official URL: https://www.nature.com/articles/ncb0508-507

Users with ORCIDS

ORCID for Kevin Petrie: ORCID iD orcid.org/0000-0002-9805-9152

Catalogue record

Date Deposited: 18 Aug 2020 13:00
Last Modified: 30 Sep 2020 10:48

Contributors

Author: Kevin Petrie ORCID iD
Author: Arthur Zelent

University Divisions

Faculty of Health Sciences and Wellbeing > School of Medicine

Subjects

Sciences > Biomedical Sciences
Sciences > Health Sciences

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