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New strategies in neuroblastoma: Therapeutic targeting of MYCN and ALK.

Barone, Giuseppe, Anderson, John, Pearson, Andrew D J, Petrie, Kevin and Chesler, Louis (2013) New strategies in neuroblastoma: Therapeutic targeting of MYCN and ALK. Clinical cancer research : an official journal of the American Association for Cancer Research, 19 (21). pp. 5814-21. ISSN 1078-0432

Item Type: Article

Abstract

Clinical outcome remains poor in patients with high-risk neuroblastoma, in which chemoresistant relapse is common following high-intensity conventional multimodal therapy. Novel treatment approaches are required. Although recent genomic profiling initiatives have not revealed a high frequency of mutations in any significant number of therapeutically targeted genes, two exceptions, amplification of the MYCN oncogene and somatically acquired tyrosine kinase domain point mutations in anaplastic lymphoma kinase (ALK), present exciting possibilities for targeted therapy. In contrast with the situation with ALK, in which a robust pipeline of pharmacologic agents is available from early clinical use in adult malignancy, therapeutic targeting of MYCN (and MYC oncoproteins in general) represents a significant medicinal chemistry challenge that has remained unsolved for two decades. We review the latest approaches envisioned for blockade of ALK activity in neuroblastoma, present a classification of potential approaches for therapeutic targeting of MYCN, and discuss how recent developments in targeting of MYC proteins seem to make therapeutic inhibition of MYCN a reality in the clinic.

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More Information

Depositing User: Kevin Petrie

Identifiers

Item ID: 12436
Identification Number: https://doi.org/10.1158/1078-0432.CCR-13-0680
ISSN: 1078-0432
URI: http://sure.sunderland.ac.uk/id/eprint/12436
Official URL: https://clincancerres.aacrjournals.org/content/19/...

Users with ORCIDS

ORCID for Kevin Petrie: ORCID iD orcid.org/0000-0002-9805-9152

Catalogue record

Date Deposited: 18 Aug 2020 18:08
Last Modified: 30 Sep 2020 10:48

Contributors

Author: Kevin Petrie ORCID iD
Author: Giuseppe Barone
Author: John Anderson
Author: Andrew D J Pearson
Author: Louis Chesler

University Divisions

Faculty of Health Sciences and Wellbeing > School of Medicine

Subjects

Sciences > Biomedical Sciences
Sciences > Health Sciences

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