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Prenatal PM2.5 Exposure and the Risk of Adverse Births Outcomes: Results from Project ELEFANT

Fang, Junkai, Kang, Choong-Min, Osorio-Yáñez, Citlalli, Barrow, Timothy, Zhang, Ruiping, Zhang, Ying, Li, Chen, Liu, Hongbin, Li, Peng-hui, Guo, Liqiong and Byun, Hyang-Min (2020) Prenatal PM2.5 Exposure and the Risk of Adverse Births Outcomes: Results from Project ELEFANT. Environmental Research. p. 110232. ISSN 0013-9351

Item Type: Article

Abstract

Background
Studies investigating the impact of fine particulate matter (PM2.5) exposure during pregnancy upon adverse birth outcomes have primarily been performed in Western nations with low ambient PM2.5 levels. We examined associations between high levels of PM2.5 exposure during pregnancy and risk of adverse birth outcomes by timing and level of exposure in a Chinese population.

Methods
We analysed data from 10,738 live births within the Project ELEFANT study based in Tianjin, China. Personal mean daily PM2.5 exposures were estimated using data from 25 local monitoring sites across the city, used to compute the days exceeding 50, 100, 150, 200 and 250 μg/m3. Relative risk of pre-term birth (<37 weeks) and low birthweight (<2500 g) were estimated by generalised additive distributed lag models, adjusted for maternal age, sex, region, paternal smoking, parity, maternal occupation, season, temperature and dew point.

Results
A dose-response was exhibited for PM2.5 exposure and relative risk (RR) of adverse birth outcomes, with exposure in the second and third trimesters of pregnancy associated with greatest risk of adverse birth outcomes. The RRs of pre-term birth with exposures of >50, >150 and >250 μg/m3 PM2.5 in the third trimester were 1.09 (95%CI: 1.03-1.16), 1.30 (1.09-1.54) and 2.73 (2.03-3.66) respectively. For low birthweight, exposures of >50, >150 and >250 μg/m3 PM2.5 in the third trimester were associated with RRs of 0.99 (0.88-1.11), 1.37 (1.04-1.81) and 3.03 (1.75-5.23) respectively.

Conclusions
Exposure to high levels of PM2.5 from the second trimester onwards were most strongly associated with increased risk of pre-term birth and low birthweight, with a dose-response relationship. Our data demonstrates the need to account for both level and timing of exposure in analysis of PM2.5-associated birth outcomes.

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More Information

Uncontrolled Keywords: Air pollutionparticulate matterPM2.5pre-term birthlow birthweight
Depositing User: Leah Maughan

Identifiers

Item ID: 12581
Identification Number: https://doi.org/10.1016/j.envres.2020.110232
ISSN: 0013-9351
URI: http://sure.sunderland.ac.uk/id/eprint/12581
Official URL: https://www.sciencedirect.com/science/article/abs/...

Users with ORCIDS

ORCID for Timothy Barrow: ORCID iD orcid.org/0000-0003-4551-3857

Catalogue record

Date Deposited: 22 Sep 2020 12:46
Last Modified: 14 Sep 2021 02:38

Contributors

Author: Timothy Barrow ORCID iD
Author: Junkai Fang
Author: Choong-Min Kang
Author: Citlalli Osorio-Yáñez
Author: Ruiping Zhang
Author: Ying Zhang
Author: Chen Li
Author: Hongbin Liu
Author: Peng-hui Li
Author: Liqiong Guo
Author: Hyang-Min Byun

University Divisions

Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences

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