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Estimated glucose disposal rate as a candidate biomarker for thrombotic biomarkers in T1D: a pooled analysis

O’Mahoney, L. L., Kietsiriroje, N., Pearson, S., West, D. J., Holmes, M., Ajjan, R. A. and Campbell, Matthew (2021) Estimated glucose disposal rate as a candidate biomarker for thrombotic biomarkers in T1D: a pooled analysis. Journal of Endocrinological Investigation. ISSN 1720-8386

Item Type: Article

Abstract

Purpose
To determine the utility of estimated glucose disposal rate (eGDR) as a candidate biomarker for thrombotic biomarkers in patients with type 1 diabetes (T1D).

Methods
We reanalysed baseline pretreatment data in a subset of patients with T1D from two previous RCTs, consisting of a panel of thrombotic markers, including fibrinogen, tissue factor (TF) activity, and plasminogen-activator inhibitor (PAI)-1, and TNFα, and clinical factors (age, T1D duration, HbA1c, insulin requirements, BMI, blood pressure, and eGDR). We employed univariate linear regression models to investigate associations between clinical parameters and eGDR with thrombotic biomarkers.

Results
Thirty-two patients were included [mean ± SD age 31 ± 7 years, HbA1c of 58 ± 9 mmol/mol (7.5 ± 0.8%), eGDR 7.73 ± 2.61]. eGDR negatively associated with fibrinogen (P < 0.001), PAI-1 concentrations (P = 0.005), and TF activity (P = 0.020), but not TNFα levels (P = 0.881). We identified 2 clusters of patients displaying significantly different characteristics; 56% (n = 18) were categorised as ‘higher-risk’, eliciting significantly higher fibrinogen (+ 1514 ± 594 μg/mL; P < 0.001), TF activity (+ 59.23 ± 9.42 pmol/mL; P < 0.001), and PAI-1 (+ 8.48 ± 1.58 pmol/dL; P < 0.001), HbA1c concentrations (+ 14.20 ± 1.04 mmol/mol; P < 0.001), age (+ 7 ± 3 years; P < 0.001), duration of diabetes (15 ± 2 years; P < 0.001), BMI (+ 7.66 ± 2.61 kg/m2; P < 0.001), and lower mean eGDR (− 3.98 ± 1.07; P < 0.001).

Conclusions
Compared to BMI and insulin requirements, classical surrogates of insulin resistance, eGDR is a suitable and superior thrombotic risk indicator in T1D.

Trial registration
ISRCTN4081115; registered 27 June 2017.

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More Information

Depositing User: Leah Maughan

Identifiers

Item ID: 13376
Identification Number: https://doi.org/10.1007/s40618-021-01550-3
ISSN: 1720-8386
URI: http://sure.sunderland.ac.uk/id/eprint/13376
Official URL: http://dx.doi.org/10.1007/s40618-021-01550-3

Users with ORCIDS

ORCID for Matthew Campbell: ORCID iD orcid.org/0000-0001-5883-5041

Catalogue record

Date Deposited: 15 Apr 2021 14:13
Last Modified: 15 Apr 2021 14:15

Contributors

Author: Matthew Campbell ORCID iD
Author: L. L. O’Mahoney
Author: N. Kietsiriroje
Author: S. Pearson
Author: D. J. West
Author: M. Holmes
Author: R. A. Ajjan

University Divisions

Faculty of Health Sciences and Wellbeing > School of Medicine

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