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Associations between erythrocyte membrane fatty acid compositions and indices of vascular health in people with type 1 diabetes with and without insulin resistance: a cross-sectional analysis. Canadian Journal of Diabetes

O’Mahoney, Lauren L., Churm, Rachel, Stavropoulos-Kalinoglou, Antonios, Ajjan, Ramzi A., Orsi, Nicolas M., Mappa, Georgia, Price, Oliver J. and Campbell, Matthew (2021) Associations between erythrocyte membrane fatty acid compositions and indices of vascular health in people with type 1 diabetes with and without insulin resistance: a cross-sectional analysis. Canadian Journal of Diabetes. Canadian Journal of Diabetes. ISSN 1499-2671

Item Type: Article

Abstract

Objectives
The aim of this study was to assess the relationship between specific erythrocyte fatty acid levels and vascular health in type 1 diabetes (T1D) with and without insulin resistance (IR).

Methods
We analyzed baseline pretreatment data in a subset of 23 patients with T1D from a previously published randomized controlled trial consisting of comprehensive erythrocyte-derived fatty acid profiles and a panel of inflammation-associated endothelial markers. Estimated glucose disposal rate was used to identify and categorize patients with IR. We utilized principal component analysis (PCA) to cluster vascular biomarkers to compute a single “vascular signal” and utilized univariate linear regression models to investigate the association with IR and fatty acid profiles.

Results
Subjects with IR displayed significantly higher levels of linoleic acid (p=0.001), lower levels of eicosapentaenoic acid (EPA) (p<0.001), lower levels of omega-3 polyunsaturated fatty acid (n-3PUFA) (p<0.006) and an increased omega-6 (n-6)PUFA:n-3PUFA ratio (p=0.001). IR was associated with significantly higher linoleic acid levels, total n-6PUFA and an increased ratio of n-6PUFA:n-3PUFA, and negatively associated with arachidonic acid and EPA levels, total saturated fatty acid and total n-3PUFA. The PCA-derived vascular biomarker cluster was positively associated with linoleic acid and n-6PUFA:n-3PUFA ratio, and inversely associated with EPA.

Conclusions
Specific erythrocyte membrane fatty acid compositions are associated with impaired vascular health and IR in adults with T1D. These findings suggest that IR and risk of associated complications may be influenced by specific fatty acid profiles, and thus potentially modified by the selective targeting of dietary fatty acids.

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More Information

Depositing User: Leah Maughan

Identifiers

Item ID: 13640
Identification Number: https://doi.org/10.1016/j.jcjd.2021.06.005
ISSN: 1499-2671
URI: http://sure.sunderland.ac.uk/id/eprint/13640
Official URL: https://www.sciencedirect.com/science/article/pii/...

Users with ORCIDS

ORCID for Matthew Campbell: ORCID iD orcid.org/0000-0001-5883-5041

Catalogue record

Date Deposited: 25 Jun 2021 14:32
Last Modified: 09 Aug 2021 09:25

Contributors

Author: Matthew Campbell ORCID iD
Author: Lauren L. O’Mahoney
Author: Rachel Churm
Author: Antonios Stavropoulos-Kalinoglou
Author: Ramzi A. Ajjan
Author: Nicolas M. Orsi
Author: Georgia Mappa
Author: Oliver J. Price

University Divisions

Faculty of Health Sciences and Wellbeing > School of Nursing and Health Sciences

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