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Characterization of Individualized Glycemic Excursions during a Standardized Bout of Hypoglycemia-Inducing Exercise and Subsequent Hypoglycemia Treatment—A Pilot Study

Brož, Jan, Campbell, Matthew D., Urbanová, Jana, Nunes, Marisa A., Brunerová, Ludmila, Rahelić, Dario, Janíčková Žďárská, Denisa, Taniwall, Arian, Brabec, Marek, Berka, Vojtěch, Michalec, Juraj and Polák, Jan (2021) Characterization of Individualized Glycemic Excursions during a Standardized Bout of Hypoglycemia-Inducing Exercise and Subsequent Hypoglycemia Treatment—A Pilot Study. Nutrients, 13 (11). e4165. ISSN 2072-6643

Item Type: Article

Abstract

The glycemic response to ingested glucose for the treatment of hypoglycemia following exercise in type 1 diabetes patients has never been studied. Therefore, we aimed to characterize glucose dynamics during a standardized bout of hypoglycemia-inducing exercise and the subsequent hypoglycemia treatment with the oral ingestion of glucose. Ten male patients with type 1 diabetes performed a standardized bout of cycling exercise using an electrically braked ergometer at a target heart rate (THR) of 50% of the individual heart rate reserve, determined using the Karvonen equation. Exercise was terminated when hypoglycemia was reached, followed by immediate hypoglycemia treatment with the oral ingestion of 20 g of glucose. Arterialized blood glucose (ABG) levels were monitored at 5 min intervals during exercise and for 60 min during recovery. During exercise, ABG decreased at a mean rate of 0.11 ± 0.03 mmol/L·min−1 (minimum: 0.07, maximum: 0.17 mmol/L·min−1). During recovery, ABG increased at a mean rate of 0.13 ± 0.05 mmol/L·min−1 (minimum: 0.06, maximum: 0.19 mmol/L·min−1). Moreover, 20 g of glucose maintained recovery from hypoglycemia throughout the 60 min postexercise observation window.

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Additional Information: ** From MDPI via Jisc Publications Router ** History: accepted 18-11-2021; pub-electronic 21-11-2021. ** Licence for this article: https://creativecommons.org/licenses/by/4.0/
Uncontrolled Keywords: type 1 diabetes, exercise, hypoglycemia, insulin therapy, glycemic excursion, hypoglycemia treatment
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SWORD Depositor: Publication Router
Depositing User: Publication Router

Identifiers

Item ID: 14206
Identification Number: https://doi.org/10.3390/nu13114165
ISSN: 2072-6643
URI: http://sure.sunderland.ac.uk/id/eprint/14206
Official URL: https://www.mdpi.com/2072-6643/13/11/4165

Users with ORCIDS

ORCID for Jan Brož: ORCID iD orcid.org/0000-0003-2465-7333
ORCID for Matthew D. Campbell: ORCID iD orcid.org/0000-0001-5883-5041
ORCID for Marisa A. Nunes: ORCID iD orcid.org/0000-0002-1864-6964
ORCID for Dario Rahelić: ORCID iD orcid.org/0000-0002-2901-0646
ORCID for Arian Taniwall: ORCID iD orcid.org/0000-0001-7174-4451

Catalogue record

Date Deposited: 09 Dec 2021 16:59
Last Modified: 25 Jan 2022 08:48

Contributors

Author: Jan Brož ORCID iD
Author: Matthew D. Campbell ORCID iD
Author: Marisa A. Nunes ORCID iD
Author: Dario Rahelić ORCID iD
Author: Arian Taniwall ORCID iD
Author: Jana Urbanová
Author: Ludmila Brunerová
Author: Denisa Janíčková Žďárská
Author: Marek Brabec
Author: Vojtěch Berka
Author: Juraj Michalec
Author: Jan Polák

University Divisions

Faculty of Health Sciences and Wellbeing > School of Nursing and Health Sciences

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