Characterization of Individualized Glycemic Excursions during a Standardized Bout of Hypoglycemia-Inducing Exercise and Subsequent Hypoglycemia Treatment—A Pilot Study
Brož, Jan, Campbell, Matthew D., Urbanová, Jana, Nunes, Marisa A., Brunerová, Ludmila, Rahelić, Dario, Janíčková Žďárská, Denisa, Taniwall, Arian, Brabec, Marek, Berka, Vojtěch, Michalec, Juraj and Polák, Jan (2021) Characterization of Individualized Glycemic Excursions during a Standardized Bout of Hypoglycemia-Inducing Exercise and Subsequent Hypoglycemia Treatment—A Pilot Study. Nutrients, 13 (11). e4165. ISSN 2072-6643
Item Type: | Article |
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Abstract
The glycemic response to ingested glucose for the treatment of hypoglycemia following exercise in type 1 diabetes patients has never been studied. Therefore, we aimed to characterize glucose dynamics during a standardized bout of hypoglycemia-inducing exercise and the subsequent hypoglycemia treatment with the oral ingestion of glucose. Ten male patients with type 1 diabetes performed a standardized bout of cycling exercise using an electrically braked ergometer at a target heart rate (THR) of 50% of the individual heart rate reserve, determined using the Karvonen equation. Exercise was terminated when hypoglycemia was reached, followed by immediate hypoglycemia treatment with the oral ingestion of 20 g of glucose. Arterialized blood glucose (ABG) levels were monitored at 5 min intervals during exercise and for 60 min during recovery. During exercise, ABG decreased at a mean rate of 0.11 ± 0.03 mmol/L·min−1 (minimum: 0.07, maximum: 0.17 mmol/L·min−1). During recovery, ABG increased at a mean rate of 0.13 ± 0.05 mmol/L·min−1 (minimum: 0.06, maximum: 0.19 mmol/L·min−1). Moreover, 20 g of glucose maintained recovery from hypoglycemia throughout the 60 min postexercise observation window.
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Additional Information: ** From MDPI via Jisc Publications Router ** History: accepted 18-11-2021; pub-electronic 21-11-2021. ** Licence for this article: https://creativecommons.org/licenses/by/4.0/ |
Uncontrolled Keywords: type 1 diabetes, exercise, hypoglycemia, insulin therapy, glycemic excursion, hypoglycemia treatment |
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Identifiers
Item ID: 14206 |
Identification Number: https://doi.org/10.3390/nu13114165 |
ISSN: 2072-6643 |
URI: http://sure.sunderland.ac.uk/id/eprint/14206 | Official URL: https://www.mdpi.com/2072-6643/13/11/4165 |
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Date Deposited: 09 Dec 2021 16:59 |
Last Modified: 25 Jan 2022 08:48 |
Author: | Jan Brož |
Author: | Matthew D. Campbell |
Author: | Marisa A. Nunes |
Author: | Dario Rahelić |
Author: | Arian Taniwall |
Author: | Jana Urbanová |
Author: | Ludmila Brunerová |
Author: | Denisa Janíčková Žďárská |
Author: | Marek Brabec |
Author: | Vojtěch Berka |
Author: | Juraj Michalec |
Author: | Jan Polák |
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