Risk factors associated with mortality in individuals with type 2 diabetes following an episode of severe hypoglycaemia. Results from a randomised controlled trial
Pearson, Sam M., Kietsiriroje, Noppadol, Whittam, Beverley, Birch, Rebecca J, Campbell, Matthew and Ajjan, Ramzi A (2022) Risk factors associated with mortality in individuals with type 2 diabetes following an episode of severe hypoglycaemia. Results from a randomised controlled trial. Diabetes and Vascular Disease Research. pp. 19-1. ISSN 1479-1641
Item Type: | Article |
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Abstract
Background
Severe hypoglycaemia may pose significant risk to individuals with type 2 diabetes (T2D), and evidence surrounding strategies to mitigate this risk is lacking.
Methods
Data was re-analysed from a previous randomised controlled trial studying the impact of nurse-led intervention on mortality following severe hypoglycaemia in the community. A Cox-regression model was used to identify baseline characteristics associated with mortality and to adjust for differences between groups. Kaplan-Meier curves were created to demonstrate differences in outcome between groups across different variables.
Results
A total of 124 participants (mean age = 75, 56.5% male) were analysed. In univariate analysis, Diabetes Severity Score (DSS), age and insulin use were baseline factors found to correlate to mortality, while HbA1C and established cardiovascular disease showed no significant correlations. Hazard ratio favoured the intervention (0.68, 95% CI: 0.38–1.19) and in multivariate analysis, only DSS demonstrated a relationship with mortality. Comparison of Kaplan-Meier curves across study groups suggested the intervention is beneficial irrespective of HbA1c, diabetes severity score or age.
Conclusion
While DSS predicts mortality following severe community hypoglycaemia in individuals with T2D, a structured nurse-led intervention appears to reduce the risk of death across a range of baseline parameters.
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More Information
Depositing User: Leah Maughan |
Identifiers
Item ID: 14209 |
Identification Number: https://doi.org/10.1177/14791641211067415 |
ISSN: 1479-1641 |
URI: http://sure.sunderland.ac.uk/id/eprint/14209 | Official URL: https://journals.sagepub.com/doi/10.1177/147916412... |
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Catalogue record
Date Deposited: 24 Nov 2021 09:36 |
Last Modified: 04 Feb 2022 10:15 |
Author: | Noppadol Kietsiriroje |
Author: | Matthew Campbell |
Author: | Sam M. Pearson |
Author: | Beverley Whittam |
Author: | Rebecca J Birch |
Author: | Ramzi A Ajjan |
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Faculty of Health Sciences and Wellbeing > School of Nursing and Health SciencesActions (login required)
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