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Risk factors associated with mortality in individuals with type 2 diabetes following an episode of severe hypoglycaemia. Results from a randomised controlled trial

Pearson, Sam M., Kietsiriroje, Noppadol, Whittam, Beverley, Birch, Rebecca J, Campbell, Matthew and Ajjan, Ramzi A (2022) Risk factors associated with mortality in individuals with type 2 diabetes following an episode of severe hypoglycaemia. Results from a randomised controlled trial. Diabetes and Vascular Disease Research. pp. 19-1. ISSN 1479-1641

Item Type: Article

Abstract

Background
Severe hypoglycaemia may pose significant risk to individuals with type 2 diabetes (T2D), and evidence surrounding strategies to mitigate this risk is lacking.

Methods
Data was re-analysed from a previous randomised controlled trial studying the impact of nurse-led intervention on mortality following severe hypoglycaemia in the community. A Cox-regression model was used to identify baseline characteristics associated with mortality and to adjust for differences between groups. Kaplan-Meier curves were created to demonstrate differences in outcome between groups across different variables.

Results
A total of 124 participants (mean age = 75, 56.5% male) were analysed. In univariate analysis, Diabetes Severity Score (DSS), age and insulin use were baseline factors found to correlate to mortality, while HbA1C and established cardiovascular disease showed no significant correlations. Hazard ratio favoured the intervention (0.68, 95% CI: 0.38–1.19) and in multivariate analysis, only DSS demonstrated a relationship with mortality. Comparison of Kaplan-Meier curves across study groups suggested the intervention is beneficial irrespective of HbA1c, diabetes severity score or age.

Conclusion
While DSS predicts mortality following severe community hypoglycaemia in individuals with T2D, a structured nurse-led intervention appears to reduce the risk of death across a range of baseline parameters.

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More Information

Depositing User: Leah Maughan

Identifiers

Item ID: 14209
Identification Number: https://doi.org/10.1177/14791641211067415
ISSN: 1479-1641
URI: http://sure.sunderland.ac.uk/id/eprint/14209
Official URL: https://journals.sagepub.com/doi/10.1177/147916412...

Users with ORCIDS

ORCID for Noppadol Kietsiriroje: ORCID iD orcid.org/0000-0002-5076-4450
ORCID for Matthew Campbell: ORCID iD orcid.org/0000-0001-5883-5041

Catalogue record

Date Deposited: 24 Nov 2021 09:36
Last Modified: 04 Feb 2022 10:15

Contributors

Author: Noppadol Kietsiriroje ORCID iD
Author: Matthew Campbell ORCID iD
Author: Sam M. Pearson
Author: Beverley Whittam
Author: Rebecca J Birch
Author: Ramzi A Ajjan

University Divisions

Faculty of Health Sciences and Wellbeing > School of Nursing and Health Sciences

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