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Pharmaceutical aspects of mAbs: formulation, characterization, and current route of administration of monoclonal antibody therapies

Elkordy, Amal and Chaw, Cheng (2023) Pharmaceutical aspects of mAbs: formulation, characterization, and current route of administration of monoclonal antibody therapies. In: Formulation of Monoclonal Antibody Therapies: From Lab to Market. Elsevier, pp. 53-207. ISBN 9780128233658

Item Type: Book Section

Abstract

Monoclonal antibodies (mAbs) are the fast-growing sector in biotherapeutics. Physical and chemical instabilities of those drug candidates pose different formulations and clinical challenges. Hence, this chapter will focus on the formulation of mAbs in the two different marketed dosage forms (dried powders and liquids) and how stabilization of therapeutic monoclonal antibodies can be enhanced with the application of techniques, buffers and excipients. Accordingly, lyophilization and diafiltration techniques will be covered in this chapter along with methods applied for characterization of their mAb products. Moreover, the current route of mAbs administration via parenteral route and its implication on formulation aspects (for example, high concentrated mAb liquid injections for subcutaneous route) will be discussed.

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More Information

Depositing User: Amal Elkordy

Identifiers

Item ID: 16199
ISBN: 9780128233658
URI: http://sure.sunderland.ac.uk/id/eprint/16199
Official URL: https://doi.org/10.1016/B978-0-12-823365-8.00004-9

Users with ORCIDS

ORCID for Amal Elkordy: ORCID iD orcid.org/0000-0002-0781-1127
ORCID for Cheng Chaw: ORCID iD orcid.org/0000-0002-7450-4100

Catalogue record

Date Deposited: 01 Jun 2023 16:39
Last Modified: 01 Jun 2023 16:39

Contributors

Author: Amal Elkordy ORCID iD
Author: Cheng Chaw ORCID iD

University Divisions

Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences

Subjects

Sciences > Pharmacy and Pharmacology
Sciences

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