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Interrupting prolonged sitting with frequent short bouts of light-intensity activity in people with type 1 diabetes improves glycaemic control without increasing hypoglycaemia: The SIT-LESS randomized controlled trial

Campbell, Matthew, Alobaid, A, Hopkins, M, Dempsey, P, Pearson, Sam, Kietsiriroje, Noppadol, Churm, Rachel and Ajjan, RA (2023) Interrupting prolonged sitting with frequent short bouts of light-intensity activity in people with type 1 diabetes improves glycaemic control without increasing hypoglycaemia: The SIT-LESS randomized controlled trial. Diabetes, Obesity and Metabolism. ISSN 1463-1326

Item Type: Article

Abstract

Aims: To examine the impact of interrupting prolonged sitting with frequent short bouts of light-intensity activity on glycaemic control in people with type 1 diabetes (T1D).

Materials and methods: 32 inactive adults with T1D (aged 27.9±4.7 years, 15 men, diabetes duration 16.0±6.9 years and HbA1c 8.4±1.4% [68±2.3 mmol/mol]) underwent two 7-hour experimental conditions in a randomised crossover fashion with >7-day washout consisting of: uninterrupted sitting (SIT), or, interrupted sitting with 3-minute bouts of self-paced walking at 30-minute intervals (SIT-LESS). Standardised mixed-macronutrient meals were administered 3.5-hours apart during each condition. Blinded continuous glucose monitoring (CGM) captured interstitial glucose responses during the 7-hour experimental period and for a further 48-hours under free-living conditions.

Results: SIT-LESS reduced total mean glucose (SIT 8.2±2.6 vs. SIT-LESS 6.9±1.7 mmol/L, P=0.001) and increased Time in Range (TIR; 3.9-10.0 mmol/L) by 13.7% (SIT 71.5±9.5 vs. SIT-LESS 85.1±7.1 %, P=0.002). Hyperglycaemia (>10.0 mmol/L) was reduced by 15.0% under SIT-LESS (SIT 24.2±10.8 vs. SIT-LESS 9.2±6.4 %, P=0.002), whereas hypoglycaemia exposure (<3.9 mmol/L) (SIT 4.6±3.0 vs. SIT-LESS 6.0±6.0 %, P=0.583) was comparable across conditions. SIT-LESS reduced glycaemic variability (CV%) by 7.8% across the observation window (P=0.021). These findings were consistent when assessing discrete time periods, with SIT-LESS improving experimental and free-living postprandial, whole-day, and night-time glycaemic outcomes (P<0.05).

Conclusions: Interrupting prolonged sitting with frequent short bouts of light-intensity activity improves acute postprandial and 48-hour glycaemia in adults with T1D. This pragmatic strategy is an efficacious approach to reducing sedentariness and increasing physical activity levels without increasing risk of hypoglycaemia in T1D.

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Diabetes Obesity Metabolism - 2023 - Campbell - Interrupting prolonged sitting with frequent short bouts of light‐intensity.pdf
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More Information

Depositing User: Matthew Campbell

Identifiers

Item ID: 16533
Identification Number: https://doi.org/10.1111/dom.15254
ISSN: 1463-1326
URI: http://sure.sunderland.ac.uk/id/eprint/16533
Official URL: https://dom-pubs.onlinelibrary.wiley.com/doi/10.11...

Users with ORCIDS

ORCID for Matthew Campbell: ORCID iD orcid.org/0000-0001-5883-5041
ORCID for Noppadol Kietsiriroje: ORCID iD orcid.org/0000-0002-5076-4450

Catalogue record

Date Deposited: 06 Sep 2023 09:20
Last Modified: 04 Oct 2024 08:30

Contributors

Author: Matthew Campbell ORCID iD
Author: Noppadol Kietsiriroje ORCID iD
Author: A Alobaid
Author: M Hopkins
Author: P Dempsey
Author: Sam Pearson
Author: Rachel Churm
Author: RA Ajjan

University Divisions

Faculty of Health Sciences and Wellbeing > School of Nursing and Health Sciences

Subjects

Sciences > Biomedical Sciences
Sciences

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