Interrupting prolonged sitting with frequent short bouts of light-intensity activity in people with type 1 diabetes improves glycaemic control without increasing hypoglycaemia: The SIT-LESS randomized controlled trial
Campbell, Matthew, Alobaid, A, Hopkins, M, Dempsey, P, Pearson, Sam, Kietsiriroje, Noppadol, Churm, Rachel and Ajjan, RA (2023) Interrupting prolonged sitting with frequent short bouts of light-intensity activity in people with type 1 diabetes improves glycaemic control without increasing hypoglycaemia: The SIT-LESS randomized controlled trial. Diabetes, Obesity and Metabolism. ISSN 1463-1326
Item Type: | Article |
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Abstract
Aims: To examine the impact of interrupting prolonged sitting with frequent short bouts of light-intensity activity on glycaemic control in people with type 1 diabetes (T1D).
Materials and methods: 32 inactive adults with T1D (aged 27.9±4.7 years, 15 men, diabetes duration 16.0±6.9 years and HbA1c 8.4±1.4% [68±2.3 mmol/mol]) underwent two 7-hour experimental conditions in a randomised crossover fashion with >7-day washout consisting of: uninterrupted sitting (SIT), or, interrupted sitting with 3-minute bouts of self-paced walking at 30-minute intervals (SIT-LESS). Standardised mixed-macronutrient meals were administered 3.5-hours apart during each condition. Blinded continuous glucose monitoring (CGM) captured interstitial glucose responses during the 7-hour experimental period and for a further 48-hours under free-living conditions.
Results: SIT-LESS reduced total mean glucose (SIT 8.2±2.6 vs. SIT-LESS 6.9±1.7 mmol/L, P=0.001) and increased Time in Range (TIR; 3.9-10.0 mmol/L) by 13.7% (SIT 71.5±9.5 vs. SIT-LESS 85.1±7.1 %, P=0.002). Hyperglycaemia (>10.0 mmol/L) was reduced by 15.0% under SIT-LESS (SIT 24.2±10.8 vs. SIT-LESS 9.2±6.4 %, P=0.002), whereas hypoglycaemia exposure (<3.9 mmol/L) (SIT 4.6±3.0 vs. SIT-LESS 6.0±6.0 %, P=0.583) was comparable across conditions. SIT-LESS reduced glycaemic variability (CV%) by 7.8% across the observation window (P=0.021). These findings were consistent when assessing discrete time periods, with SIT-LESS improving experimental and free-living postprandial, whole-day, and night-time glycaemic outcomes (P<0.05).
Conclusions: Interrupting prolonged sitting with frequent short bouts of light-intensity activity improves acute postprandial and 48-hour glycaemia in adults with T1D. This pragmatic strategy is an efficacious approach to reducing sedentariness and increasing physical activity levels without increasing risk of hypoglycaemia in T1D.
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Diabetes Obesity Metabolism - 2023 - Campbell - Interrupting prolonged sitting with frequent short bouts of light‐intensity.pdf Available under License Creative Commons Attribution. Download (1MB) | Preview |
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Depositing User: Matthew Campbell |
Identifiers
Item ID: 16533 |
Identification Number: https://doi.org/10.1111/dom.15254 |
ISSN: 1463-1326 |
URI: http://sure.sunderland.ac.uk/id/eprint/16533 | Official URL: https://dom-pubs.onlinelibrary.wiley.com/doi/10.11... |
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Catalogue record
Date Deposited: 06 Sep 2023 09:20 |
Last Modified: 04 Oct 2024 08:30 |
Author: | Matthew Campbell |
Author: | Noppadol Kietsiriroje |
Author: | A Alobaid |
Author: | M Hopkins |
Author: | P Dempsey |
Author: | Sam Pearson |
Author: | Rachel Churm |
Author: | RA Ajjan |
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Faculty of Health Sciences and Wellbeing > School of Nursing and Health SciencesSubjects
Sciences > Biomedical SciencesSciences
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