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Analysis of omeprazole and esomeprazole obtained from traditional pharmacies and unlicensed internet websites using Raman spectroscopy, 1H-NMR and chemometric analysis

Bellia, Gaetano F., Gil-Ramirez, Guzman, Baron, Mark G., Croxton, Ruth and Gonzalez-Rodriguez, Jose (2020) Analysis of omeprazole and esomeprazole obtained from traditional pharmacies and unlicensed internet websites using Raman spectroscopy, 1H-NMR and chemometric analysis. Vibrational Spectroscopy, 106 (102996). ISSN 0924-2031

Item Type: Article

Abstract

The relevant therapeutic outcomes obtained with the use of proton pump inhibitors for the treatment of gastric conditions have an important reflection on the prescribing habits of clinicians of primary and secondary care organizations. With the attempt to reduce their financial impact on the health systems, generic medications, obtained both from tradition distribution chain and from parallel import, have represented the main type of proton pump inhibitors used in clinics recently. The effect of parallel import and the use of the internet as an international distribution network significantly facilitates the entry of falsified medicines in the official channels of distribution. Since the interchangeability of different omeprazole preparations has been previously questioned, in this study we used Raman and 1H-NMR to characterise different omeprazole and esomeprazole formulations produced by different manufacturers and obtained from both traditional pharmacies and from unlicensed internet market in order to establish if any differences could be found to substantiate any different clinical performances. A chemometric study of Raman spectra allowed partial separation indicating that there are not sufficient chemical differences for PCA groups to be established using this analytical approach and for these specific medications. On the contrary, NMR investigations allowed the identification of impurities in internet samples, not detected by the Raman analyses, making this technique a valid candidate analytical tool to adopt for the investigation of falsified medicines.

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More Information

Depositing User: Ruth Croxton

Identifiers

Item ID: 16575
Identification Number: https://doi.org/10.1016/j.vibspec.2019.102996
ISSN: 0924-2031
URI: http://sure.sunderland.ac.uk/id/eprint/16575
Official URL: https://www.sciencedirect.com/science/article/pii/...

Users with ORCIDS

ORCID for Ruth Croxton: ORCID iD orcid.org/0000-0002-4027-7077

Catalogue record

Date Deposited: 26 Feb 2024 10:24
Last Modified: 26 Feb 2024 10:30

Contributors

Author: Ruth Croxton ORCID iD
Author: Gaetano F. Bellia
Author: Guzman Gil-Ramirez
Author: Mark G. Baron
Author: Jose Gonzalez-Rodriguez

University Divisions

Faculty of Health Sciences and Wellbeing > School of Psychology

Subjects

Sciences > Chemistry

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