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Type VI secretion: a beginner's guide

Bingle, Lewis, Bailey, Christopher M and Pallen, Mark J (2008) Type VI secretion: a beginner's guide. Current Opinion in Microbiology, 11 (1). pp. 3-8. ISSN 1369-5274

Item Type: Article

Abstract

Type VI secretion is a newly described mechanism for protein transport across the cell envelope of Gram-negative bacteria. Components that have been partially characterised include an IcmF homologue, the ATPase ClpV, a regulatory FHA domain protein and the secreted VgrG and Hcp proteins. Type VI secretion is clearly a key virulence factor for some important pathogenic bacteria and has been implicated in the translocation of a potential effector protein into eukaryotic cells by at least one organism (Vibrio cholerae). However, type VI secretion systems (T6SSs) are widespread in nature and not confined to known pathogens. In accordance with the general rule that the expression of protein secretion systems is tightly regulated, expression of type VI secretion is controlled at both transcriptional and post-transcriptional levels.

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Depositing User: Lewis Bingle

Identifiers

Item ID: 3062
Identification Number: https://doi.org/10.1016/j.mib.2008.01.006
ISSN: 1369-5274
URI: http://sure.sunderland.ac.uk/id/eprint/3062
Official URL: http://www.sciencedirect.com/science/article/pii/S...

Users with ORCIDS

ORCID for Lewis Bingle: ORCID iD orcid.org/0000-0001-5168-5167

Catalogue record

Date Deposited: 24 Jul 2012 14:27
Last Modified: 18 Dec 2019 15:34

Contributors

Author: Lewis Bingle ORCID iD
Author: Christopher M Bailey
Author: Mark J Pallen

University Divisions

Faculty of Health Sciences and Wellbeing
Faculty of Health Sciences and Wellbeing > School of Nursing and Health Sciences

Subjects

Sciences > Biomedical Sciences

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