SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53
Lynch, CJ, Shah, ZH, Allison, SJ, Ahmed, Shafiq, Ford, J, Warnock, LJ, Li, H, Serrano, M and Milner, J
(2010)
SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53.
PLoS ONE, 4 (10).
Abstract
The NAD-dependent deacetylase SIRT1 is a nutrient-sensitive coordinator of stress-tolerance, multiple homeostatic processes and healthspan, while p53 is a stress-responsive transcription factor and our paramount tumour suppressor. Thus, SIRT1-mediated inhibition of p53 has been identified as a key node in the common biology of cancer, metabolism, development and ageing. However, precisely how SIRT1 integrates such diverse processes remains to be elucidated.
Full text not available from this repository.
More Information
Identifiers
Users with ORCIDS
Catalogue record
| Date Deposited: 16 Feb 2016 12:04 |
| Last Modified: 04 Jun 2025 17:38 |
