SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53
Lynch, CJ, Shah, ZH, Allison, SJ, Ahmed, Shafiq, Ford, J, Warnock, LJ, Li, H, Serrano, M and Milner, J (2010) SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53. PLoS ONE, 4 (10).
| Item Type: | Article |
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Abstract
The NAD-dependent deacetylase SIRT1 is a nutrient-sensitive coordinator of stress-tolerance, multiple homeostatic processes and healthspan, while p53 is a stress-responsive transcription factor and our paramount tumour suppressor. Thus, SIRT1-mediated inhibition of p53 has been identified as a key node in the common biology of cancer, metabolism, development and ageing. However, precisely how SIRT1 integrates such diverse processes remains to be elucidated.
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| Depositing User: Paula Normington |
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| Item ID: 6011 |
| Identification Number: https://doi.org/10.1371/journal.pone.0013502 |
| URI: http://sure.sunderland.ac.uk/id/eprint/6011 |
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| Date Deposited: 16 Feb 2016 12:04 |
| Last Modified: 18 Dec 2019 15:38 |
| Author: |
Shafiq Ahmed
|
| Author: | CJ Lynch |
| Author: | ZH Shah |
| Author: | SJ Allison |
| Author: | J Ford |
| Author: | LJ Warnock |
| Author: | H Li |
| Author: | M Serrano |
| Author: | J Milner |
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Faculty of Health Sciences and WellbeingFaculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences
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