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Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53

Lynch, CJ, Shah, ZH, Allison, SJ, Ahmed, Shafiq, Ford, J, Warnock, LJ, Li, H, Serrano, M and Milner, J (2010) SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53. PLoS ONE, 4 (10).

Item Type: Article

Abstract

The NAD-dependent deacetylase SIRT1 is a nutrient-sensitive coordinator of stress-tolerance, multiple homeostatic processes and healthspan, while p53 is a stress-responsive transcription factor and our paramount tumour suppressor. Thus, SIRT1-mediated inhibition of p53 has been identified as a key node in the common biology of cancer, metabolism, development and ageing. However, precisely how SIRT1 integrates such diverse processes remains to be elucidated.

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More Information

Depositing User: Paula Normington

Identifiers

Item ID: 6011
Identification Number: https://doi.org/10.1371/journal.pone.0013502
URI: http://sure.sunderland.ac.uk/id/eprint/6011

Users with ORCIDS

ORCID for Shafiq Ahmed: ORCID iD orcid.org/0000-0001-8701-6889

Catalogue record

Date Deposited: 16 Feb 2016 12:04
Last Modified: 18 Dec 2019 15:38

Contributors

Author: Shafiq Ahmed ORCID iD
Author: CJ Lynch
Author: ZH Shah
Author: SJ Allison
Author: J Ford
Author: LJ Warnock
Author: H Li
Author: M Serrano
Author: J Milner

University Divisions

Faculty of Health Sciences and Wellbeing
Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences

Subjects

Sciences

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