Unusual Adsorption Effects on Inert HPLC Components
Hambleton, Paul, Lough, John, Mills, M.J. and Maltas, J. (1995) Unusual Adsorption Effects on Inert HPLC Components. Journal of Liquid Chromatography, 18 (16). pp. 3205-3217. ISSN 10826079508010445
| Item Type: | Article |
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Abstract
The use of injector loops made of the inert polymer PEEKTM was studied for the analysis of non-steroidal anti-inflammatory drugs (NSAID) using microbore LC with peak compression. Surprisingly it was found that the use of PEEK not only failed to prevent adsorption of analyte in the loop but, in this instance, actually exacerbated the problem. The effect of loop overfill volume, competing NSAID in the sample solution and percentage organic component in the mobile phase on this phenomenon was investigated. Comparison was also made between PEEKTM and other materials used for injector loops.
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| Depositing User: Paula Normington |
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| Item ID: 6405 |
| ISSN: 10826079508010445 |
| URI: http://sure.sunderland.ac.uk/id/eprint/6405 | Official URL: http://www.tandfonline.com/doi/abs/10.1080/1082607... |
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| Date Deposited: 12 Jun 2017 10:46 |
| Last Modified: 18 Dec 2019 15:39 |
| Author: | Paul Hambleton |
| Author: | John Lough |
| Author: | M.J. Mills |
| Author: | J. Maltas |
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Faculty of Health Sciences and WellbeingFaculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences
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