Characterisation and in vitro stability of low-dose, lidocaine-loaded poly(vinyl alcohol)-tetrahydroxyborate hydrogels
Abdelkader, D H, Osman, M.A., El-Gizawy, S.A., Faheem, Ahmed and McCarron, P.A. (2016) Characterisation and in vitro stability of low-dose, lidocaine-loaded poly(vinyl alcohol)-tetrahydroxyborate hydrogels. International Journal of Pharmaceutics, 500 (1-2). pp. 326-335. ISSN 0378-5173
Item Type: | Article |
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Abstract
Poly(vinyl alcohol) hydrogels cross-linked with the tetrahydroxyborate anion possess textural and rheological properties that can be used as novel drug-loaded vehicles for application to traumatic wounds. However, addition of soluble drug substances causes concentration-dependent phase separation and rheological changes. The aim of this work was to investigate the effect of adding a local anaesthetic, but keeping the concentration low in an attempt to prevent these changes. Cross-linked hydrogels prepared from three grades of poly(vinyl alcohol) were characterised rheologically. Temperature sweep studies showed an elevated complex viscosity upon moving from 25 °C to 80 °C, which remained high for 48 h following completion of the cycle. Adhesion to model dermal surfaces achieved a maximum of 2.62 N cm−2 and were greater than that observed to epidermal substrates, with a strong dependence on the rate of detachment used during testing. An optimised formulation (6% w/w PVA (31–50; 99) and 2% w/w THB) containing lidocaine hydrochloride loaded to an upper maximum concentration of 1.5% w/w was assessed for phase separation and drug crystallisation. After six months, crystallisation was present in formulations containing 0.7% and 1.5% lidocaine HCl. Changes in pH in response to increases in lidocaine loading were low. Drug release was shown to operate via a non-Fickian process for all three concentrations, with 60% occurring after approximately 24 h. It can be concluded that using a low concentration of lidocaine hydrochloride in hydrogels based on poly(vinyl alcohol) will result in crystallisation. Furthermore, these hydrogels are unlikely to induce rapid anaesthesia due to the low loading and slow release kinetics.
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Depositing User: Barry Hall |
Identifiers
Item ID: 6769 |
Identification Number: https://doi.org/10.1016/j.ijpharm.2016.01.046 |
ISSN: 0378-5173 |
URI: http://sure.sunderland.ac.uk/id/eprint/6769 | Official URL: https://www.sciencedirect.com/science/article/pii/... |
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Catalogue record
Date Deposited: 31 Oct 2016 15:35 |
Last Modified: 05 Feb 2020 16:44 |
Author: | D H Abdelkader |
Author: | M.A. Osman |
Author: | S.A. El-Gizawy |
Author: | Ahmed Faheem |
Author: | P.A. McCarron |
University Divisions
Faculty of Health Sciences and WellbeingFaculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences
Subjects
Sciences > Pharmacy and PharmacologySciences
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