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Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

Allosteric Integrase Inhibitors

Hann, Victoria, Dawson, Peter and Ashton, Mark (2016) Allosteric Integrase Inhibitors. In: Frontiers in Clinical Drug Research-HIV. Bentham Science Publishers, UAE, pp. 49-126. ISBN 9781681082301

Item Type: Book Section

Abstract

In the recent years, integrase (IN) has emerged as an important new target for the development of anti-HIV-1 agents. The enzyme is involved in a key stage of the retroviral replicative cycle, and interacts with a range of cellular co-factors. Due to the absolute necessity of the enzyme for successful infection and the range of cellular cofactors employed by the enzyme, new ways of targeting both IN and its cofactors could yield agents with improved resistance profiles. Allosteric inhibitors are currently receiving a great deal of focus from both academia and industry alike and offer the possibility of a new class of anti-HIV-1 inhibitor.

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More Information

Depositing User: Barry Hall

Identifiers

Item ID: 6903
Identification Number: https://doi.org/10.2174/97816810822951160301
ISBN: 9781681082301
URI: http://sure.sunderland.ac.uk/id/eprint/6903
Official URL: http://ebooks.benthamscience.com/book/978168108229...

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Catalogue record

Date Deposited: 30 Jan 2017 16:29
Last Modified: 02 Jun 2021 10:54

Contributors

Author: Victoria Hann
Author: Peter Dawson
Author: Mark Ashton

University Divisions

Faculty of Health Sciences and Wellbeing

Subjects

Sciences > Biomedical Sciences

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