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Evaluation of the functionality of biodegradable polymeric platforms for drug delivery systems

Gioti, M., Karagkiozaki, V., Basgiouraki, A., Karagiannidis, Panagiotis and Logothetidis, S. (2013) Evaluation of the functionality of biodegradable polymeric platforms for drug delivery systems. Applied Surface Science, 281. pp. 54-59. ISSN 01694332

Item Type: Article

Abstract

We present the development of a drug-loaded triple-layer platform consisting of thin film biodegradable polymers, in a properly designed form for the desired gradual degradation. Poly(dl-lactide-co-glycolide) (PLGA (65:35), PLGA (75:25)) and polycaprolactone (PCL) were grown by spin coating technique, to synthesize the platforms with the order PCL/PLGA (75:25)/PLGA (65:35) that determine their degradation rates. The outer PLGA (65:35) layer was loaded with dipyridamole, an antiplatelet drug. Spectroscopic ellipsometry (SE) in the Vis-far UV range was used to determine the nanostructure, as well as the content of the incorporated drug in the as-grown platforms. In situ and real-time SE measurements were carried out using a liquid cell for the dynamic evaluation of the fibrinogen and albumin protein adsorption processes. Atomic force microscopy studies justified the SE results concerning the nanopores formation in the polymeric platforms, and the dominant adsorption mechanisms of the proteins, which were defined by the drug incorporation in the platforms.

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More Information

Depositing User: Panagiotis Karagiannidis

Identifiers

Item ID: 7765
Identification Number: https://doi.org/10.1016/j.apsusc.2013.04.082
ISSN: 01694332
URI: http://sure.sunderland.ac.uk/id/eprint/7765
Official URL: https://doi.org/10.1016/j.apsusc.2013.04.082

Users with ORCIDS

ORCID for Panagiotis Karagiannidis: ORCID iD orcid.org/0000-0002-2709-4161

Catalogue record

Date Deposited: 21 Sep 2017 15:24
Last Modified: 18 Dec 2019 15:41

Contributors

Author: Panagiotis Karagiannidis ORCID iD
Author: M. Gioti
Author: V. Karagkiozaki
Author: A. Basgiouraki
Author: S. Logothetidis

University Divisions

Faculty of Technology
Faculty of Technology > School of Engineering

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