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Feasibility of using gluconolactone, trehalose and hydroxy-propyl gamma cyclodextrin to enhance bendroflumethiazide dissolution using lyophilisation and physical mixing techniques

Saleh, Ashraf, McGarry, Kenneth, Chaw, Cheng and Elkordy, Amal (2018) Feasibility of using gluconolactone, trehalose and hydroxy-propyl gamma cyclodextrin to enhance bendroflumethiazide dissolution using lyophilisation and physical mixing techniques. Pharmaceutics, 10 (1). pp. 1-16. ISSN 1999-4923

Item Type: Article

Abstract

PURPOSE:
Hydrophobic drugs are facing a major challenge in dissolution rate enhancement and solubility in aqueous solutions; therefore, a variety of methods have been used to improve dissolution rate and/or solubility of bendroflumethiazide as a model hydrophobic drug.

METHODS:
In this study, two main methods (physical mixing and lyophilisation) were used with gluconolactone, hydroxyl propyl γ-ccyclodextrin, and trehalose to explore this challenge. Bendroflumethiazide, practically insoluble in water, was mixed with one of the three excipients gluconolactone, hydroxyl propyl γ-cyclodextrin, and trehalose in three different ratios 1:1, 1:2, 1:5. To the best of our knowledge, the dissolution of the drug has not been previously enhanced by using either these methods or any of the used excipients. Samples containing drug and each of the excipients were characterized via dissolution testing, Fourier Transform infra-red spectroscopy, differential scanning calorimetry, and scanning electron microscopy.

RESULTS:
The used methods showed a significant enhancement in dug dissolution rate; physical mixing significantly, p < 0.05, increased the percentage of the drug released with time; for example, bendroflumethiazide dissolution in distilled water was improved from less than 20% to 99.79% within 90 min for physically mixed drug-cyclodextrin 1:5. The lyophilisation process was enhanced and the drug dissolution rate and the highest drug dissolution was achieved for (drug-gluconolactone 1:1) with 98.98% drug release within 90 min.

CONCLUSIONS:
the physical mixing and freeze drying processes significantly increased the percentage of drug release with time.

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More Information

Depositing User: Amal Elkordy

Identifiers

Item ID: 8775
Identification Number: https://doi.org/10.3390/pharmaceutics10010022
ISSN: 1999-4923
URI: http://sure.sunderland.ac.uk/id/eprint/8775
Official URL: http://www.mdpi.com/journal/pharmaceutics

Users with ORCIDS

ORCID for Kenneth McGarry: ORCID iD orcid.org/0000-0002-9329-9835
ORCID for Cheng Chaw: ORCID iD orcid.org/0000-0002-7450-4100
ORCID for Amal Elkordy: ORCID iD orcid.org/0000-0002-0781-1127

Catalogue record

Date Deposited: 19 Feb 2018 14:17
Last Modified: 16 May 2022 13:00