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Salivary Cytokines in Healthy Adolescent Girls: Intercorrelations, Stability, and Associations with Serum Cytokines, Age and Pubertal Stage.

Riis, JL, Out, D, Dorn, LD, Beal, SJ, Denson, LA, Pabst, S, Jaedicke, Katrin and Granger, DA (2013) Salivary Cytokines in Healthy Adolescent Girls: Intercorrelations, Stability, and Associations with Serum Cytokines, Age and Pubertal Stage. Developmental Psychobiology, 56 (4). pp. 797-811. ISSN 0012-1630

Item Type: Article

Abstract

Theoretically, the measurement of cytokines in saliva may have utility for studies of brain, behavior, and immunity in youth. Cytokines in saliva and serum were analyzed across three annual assessments in healthy adolescent girls (N = 114, 11-17 years at enrollment). Samples were assayed for GM-CSF, IFNγ, IL-1β, IL-2, IL-6, IL-8, IL-10, IL-12p70, TNFα, adiponectin, and cotinine. Results revealed: (1) cytokine levels, except IFNγ and IL-10, were detectable in saliva, and salivary levels, except IL-8 and IL-1β, were lower than serum levels; (2) salivary cytokine levels were lower in older girls and positively associated with adiponectin; (3) compared to serum levels, the correlations between salivary cytokines were higher, but salivary cytokines were less stable across years; and (4) except for IL-1β, there were no significant serum-saliva associations. Variation in basal salivary cytokine levels in healthy adolescent girls reflect compartmentalized activity of the oral mucosal immune system, rather than systemic cytokine activity.

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More Information

Depositing User: Katrin Jaedicke

Identifiers

Item ID: 9355
Identification Number: https://doi.org/10.1002/dev.21149
ISSN: 0012-1630
URI: http://sure.sunderland.ac.uk/id/eprint/9355
Official URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/de...

Users with ORCIDS

ORCID for Katrin Jaedicke: ORCID iD orcid.org/0000‐0002‐7389‐5816

Catalogue record

Date Deposited: 16 May 2018 12:23
Last Modified: 18 Dec 2019 16:06

Contributors

Author: Katrin Jaedicke ORCID iD
Author: JL Riis
Author: D Out
Author: LD Dorn
Author: SJ Beal
Author: LA Denson
Author: S Pabst
Author: DA Granger

University Divisions

Faculty of Health Sciences and Wellbeing
Faculty of Health Sciences and Wellbeing > School of Nursing and Health Sciences

Subjects

Sciences > Health Sciences

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