Brief Effect of a Small Hydrophobic Drug (Cinnarizine) on the Physicochemical Characterisation of Niosomes Produced by Thin-Film Hydration and Microfluidic Methods

Yeo, Li Key, Olusanya, Temidayo O.B., Chaw, Cheng and Elkordy, Amal (2018) Brief Effect of a Small Hydrophobic Drug (Cinnarizine) on the Physicochemical Characterisation of Niosomes Produced by Thin-Film Hydration and Microfluidic Methods. Pharmaceutics, 10 (4). p. 185. ISSN 1999-4923

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Abstract

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Open AccessArticle
Brief Effect of a Small Hydrophobic Drug (Cinnarizine) on the Physicochemical Characterisation of Niosomes Produced by Thin-Film Hydration and Microfluidic Methods
by Li Key YeoOrcID,Temidayo O. B. Olusanya,Cheng Shu Chaw andAmal Ali Elkordy *OrcID
School of Pharmacy and Pharmaceutical Sciences, University of Sunderland, Sunderland SR1 3SD, UK
*
Author to whom correspondence should be addressed.
Pharmaceutics 2018, 10(4), 185; https://doi.org/10.3390/pharmaceutics10040185
Received: 20 July 2018 / Revised: 5 October 2018 / Accepted: 9 October 2018 / Published: 13 October 2018
(This article belongs to the Special Issue Non-Ionic Surfactant Vesicles for Drug Delivery)
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Abstract
Novel niosomal formulations containing cinnarizine were developed to enhance its drug characteristics. In this work, niosomes (non-ionic surfactant vesicles) were prepared by conventional thin-film hydration (TFH) and microfluidic (MF) methods with sorbitan monostearate (Span® 60), cholesterol, and co-surfactants (Cremophor® ELP, Cremophor® RH40 and Solutol® HS15) as key excipients. The aim was to study the effect of cinnarizine on the characteristics of different niosomal formulations manufactured by using different methods. For effective targeted oral drug delivery, the efficacy of niosomes for therapeutic applications is correlated to their physiochemical properties. Niosome vesicles prepared were characterised using dynamic light scattering technique and the morphology of niosomes dispersion was characterised using optical microscopy. Dialysis was carried out to purify niosome suspensions to determine drug loading and drug release studies was performed to study the potential use of niosomal systems for cinnarizine.

Item Type: Article
Subjects: Sciences > Pharmacy and Pharmacology
Divisions: Faculty of Health Sciences and Wellbeing
Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences
Depositing User: Amal Elkordy
Date Deposited: 16 Oct 2018 08:47
Last Modified: 19 Aug 2020 14:35
URI: http://sure.sunderland.ac.uk/id/eprint/10054
ORCID for Cheng Chaw: ORCID iD orcid.org/0000-0002-7450-4100

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