Background: Group B streptococcus (GBS) is the most common cause of neonatal sepsis in United Kingdom (UK). Early onset sepsis (EOS), but not late onset sepsis (LOS) can be prevented by providing intrapartum antibiotic prophylaxis (IAP). In spite of national guidelines since 2003, the incidence of neonatal GBS infections is increasing in UK.
Aim: To assess the incidence of culture proven GBS infections before and after a change of practice on antepartum management of GBS in babies <3 months of age, born at Sunderland Royal Hospital between 1st Jan 2008 and 31st December 2017.

Setting: Tertiary neonatal unit

Study design: Retrospective cohort study

Methods: Babies presenting with signs of sepsis from birth up to 3 months of age were included. Data regarding risk factors, intrapartum antibiotic prophylaxis and outcome of babies were collected.

Results: 29 cases were identified and presented in two epochs – before and after changing guidelines for antepartum and intrapartum management. There was a statistically significant reduction in EOS rates and no difference in LOS rates.