C-Terminal 1-Aminoethyltetrazole-Containing Oligopeptides as Novel Alanine Racemase Inhibitors

Kondacs, Laszlo A., Orenga, Sylvain, Anderson, Rosaleen J., Marrs, Emma C.L., Perry, John D. and Gray, Mark (2020) C-Terminal 1-Aminoethyltetrazole-Containing Oligopeptides as Novel Alanine Racemase Inhibitors. Molecules, 25 (6). e1315. ISSN 1420-3049

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Abstract

In clinical culture media inoculated with patient samples, selective inhibition of commensal bacteria is essential for accurate diagnosis and effective treatment, as they can mask the presence of pathogenic bacteria. The alanine analogue, 1-aminoethyltetrazole was investigated as a potential alanine racemase inhibitor. For effective uptake and enhanced and selective antibacterial activity, a library of C-terminal 1-aminoethyltetrazole containing di- and oligopeptides were synthesized by solid phase peptide coupling techniques. The investigation of the antimicrobial activity of the synthesised compounds identified several clinically applicable selective inhibitors. These enabled differentiation between the closely related bacteria, Salmonella and Escherichia coli, which can be difficult to discriminate between in a clinical setting. In addition, differentiation between enterococci and other Gram-positive cocci was also seen.

Item Type: Article
Additional Information: ** From MDPI via Jisc Publications Router ** History: accepted 09-03-2020; pub-electronic 13-03-2020. ** Licence for this article: https://creativecommons.org/licenses/by/4.0/
Uncontrolled Keywords: alanine racemase, 1-aminoethyltetrazole, antibacterial agent, selective inhibition, solid phase peptide synthesis
Divisions: Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences
Related URLs:
SWORD Depositor: Publication Router
Depositing User: Publication Router
Date Deposited: 25 Mar 2020 09:47
Last Modified: 25 Mar 2020 09:47
URI: http://sure.sunderland.ac.uk/id/eprint/11864

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