Synthesis and Antimicrobial Activity of Phosphonopeptide Derivatives Incorporating Single and Dual Inhibitors

Ng, Keng Tiong, Perry, John D., Marrs, Emma C.L., Orenga, Sylvain, Anderson, Rosaleen and Gray, Mark (2020) Synthesis and Antimicrobial Activity of Phosphonopeptide Derivatives Incorporating Single and Dual Inhibitors. Molecules, 25 (7). e1557. ISSN 1420-3049

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Abstract

In diagnostic microbiology, culture media are widely used for detection of pathogenic bacteria. Such media employ various ingredients to optimize detection of specific pathogens such as chromogenic enzyme substrates and selective inhibitors to reduce the presence of commensal bacteria. Despite this, it is rarely possible to inhibit the growth of all commensal bacteria, and thus pathogens can be overgrown and remain undetected. One approach to attempt to remedy this is the use of “suicide substrates” that can target specific bacterial enzymes and selectively inhibit unwanted bacterial species. With the purpose of identifying novel selective inhibitors, six novel phosphonopeptide derivatives based on d/l-fosfalin and β-chloro-l-alanine were synthesized and tested on 19 different strains of clinically relevant bacteria. Several compounds show potential as useful selective agents that could be exploited in the recovery of several bacterial pathogens including Salmonella, Pseudomonas aeruginosa, and Listeria.

Item Type: Article
Additional Information: ** From MDPI via Jisc Publications Router ** History: accepted 20-03-2020; pub-electronic 28-03-2020. ** Licence for this article: https://creativecommons.org/licenses/by/4.0/
Uncontrolled Keywords: bacterial detection, suicide substrates, fosfalin, β-chloroalanine
Divisions: Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences
Related URLs:
SWORD Depositor: Publication Router
Depositing User: Publication Router
Date Deposited: 30 Mar 2020 13:51
Last Modified: 15 Sep 2020 08:46
URI: http://sure.sunderland.ac.uk/id/eprint/11888
ORCID for Keng Tiong Ng: ORCID iD orcid.org/0000-0002-2943-6727
ORCID for John D. Perry: ORCID iD orcid.org/0000-0001-7225-7508
ORCID for Mark Gray: ORCID iD orcid.org/0000-0002-0674-1999

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