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Insights into the Effect of Trehalose and Cyclodextrin Molecules on Dissolution Characteristics of Furosemide Lyophilised Powder

Saleh, Ashraf, Elkordy, Amal, Chaw, Cheng, McGarry, Kenneth and Essa, Ebtessam (2020) Insights into the Effect of Trehalose and Cyclodextrin Molecules on Dissolution Characteristics of Furosemide Lyophilised Powder. Open Access Journal of Pharmaceutical Research, 4. ISSN 2574-7797

Item Type: Article


The aim of this work is to enhance the dissolution of furosemide, a hydrophobic drug used in treating hypertension. Solid dispersion via lyophilisation was employed for this purpose. Sugar and oligosaccharide, trehalose and hydroxyl propyl-γ-cyclodextrin (HP-γ-CD), were used as carrier molecules. Complexation of drug molecules with cyclodextrins changes its physical properties, including solubility. Trehalose was selected as it is a hydrophilic molecule as well as it reduces the cellular oxidative stress. Binary solid dispersions at three weight ratios drug to sugar/oligosaccharide were prepared. Solid dispersions were compared with unprocessed drug molecules and the marketed product. Samples were characterized via Fourier transform infrared spectroscopy, differential scanning calorimetry and In vitro drug dissolution. All lyophilized samples showed a significant improvement (p < 0.05) in furosemide dissolution in the aqueous dissolution medium. The study introduces furosemide/HP-γ-CD and furosemide/trehalose freeze dried composites as potential candidate powders to formulate for example fast disintegrating tablets.

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Depositing User: Amal Elkordy


Item ID: 12136
Identification Number:
ISSN: 2574-7797
Official URL:

Users with ORCIDS

ORCID for Amal Elkordy: ORCID iD
ORCID for Cheng Chaw: ORCID iD
ORCID for Kenneth McGarry: ORCID iD

Catalogue record

Date Deposited: 19 Jun 2020 09:15
Last Modified: 16 May 2022 13:01


Author: Amal Elkordy ORCID iD
Author: Cheng Chaw ORCID iD
Author: Kenneth McGarry ORCID iD
Author: Ashraf Saleh
Author: Ebtessam Essa

University Divisions

Faculty of Health Sciences and Wellbeing


Sciences > Pharmacy and Pharmacology

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