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Petrie, Kevin and Zelent, Arthur (2008) Marked for death. Nature cell biology, 10 (5). pp. 507-9. ISSN 1476-4679

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Abstract

Abstract

SUMOylation of PML–RARα oncoprotein has been linked to its arsenic-induced degradation and the therapeutic response in acute promyelocytic leukaemia. Two groups identify PML as an in vivo target of the RING finger ubiquitin E3 ligase RNF4, which specifically binds polySUMOylated PML and is essential for the arsenic-induced catabolism of both PML and PML–RARα.

Item Type: Article
Depositing User: Kevin Petrie
URI: https://sure.sunderland.ac.uk/id/eprint/12430

Further Details

More Information

Depositing User
Kevin Petrie

Identifiers

Item ID
12430
Identification Number
10.1038/ncb0508-507
ISSN
1476-4679

Users with ORCIDS

ORCID for Kevin Petrie
ORCID iD orcid.org/0000-0002-9805-9152

Catalogue record

Date Deposited
18 Aug 2020 13:00
Last Modified
04 Jun 2025 16:18

Contributors

Author
Kevin Petrie ORCID iD
Author
Arthur Zelent

University Divisions

Faculty of Health Sciences and Wellbeing > School of Medicine

Subjects

Sciences > Biomedical Sciences
Sciences > Health Sciences

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