Marked for death.

Petrie, Kevin and Zelent, Arthur (2008) Marked for death. Nature cell biology, 10 (5). pp. 507-9. ISSN 1476-4679

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Abstract

SUMOylation of PML–RARα oncoprotein has been linked to its arsenic-induced degradation and the therapeutic response in acute promyelocytic leukaemia. Two groups identify PML as an in vivo target of the RING finger ubiquitin E3 ligase RNF4, which specifically binds polySUMOylated PML and is essential for the arsenic-induced catabolism of both PML and PML–RARα.

Item Type: Article
Subjects: Sciences > Biomedical Sciences
Sciences > Health Sciences
Divisions: Faculty of Health Sciences and Wellbeing > School of Medicine
Depositing User: Kevin Petrie
Date Deposited: 18 Aug 2020 13:00
Last Modified: 19 Aug 2020 09:52
URI: http://sure.sunderland.ac.uk/id/eprint/12430
ORCID for Kevin Petrie: ORCID iD orcid.org/0000-0002-9805-9152

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