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Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

Treatment of periodontitis reduces systemic inflammation in type 2 diabetes

Preshaw, Philip M., Taylor, John J., Jaedicke, Katrin, De Jager, Marco, Bikker, Jan Willem, Selten, Wieke, Bissett, Susan M., Whall, Kerry M., van de Merwe, Rachel, Areibi, Aisha, Jitprasertwong, Paiboon, Al-Shahwani, Rana, Weaver, Jolanta, Taylor, Roy and Wassall, Rebecca R. (2020) Treatment of periodontitis reduces systemic inflammation in type 2 diabetes. Journal of Clinical Periodontology, 47. pp. 737-746. ISSN 0303-6979

Item Type: Article


Aims: To assess the impact of periodontal treatment on systemic inflammation in type 2 diabetes.

Materials and methods: Adults with type 2 diabetes (n = 83) and without diabetes (controls, n = 75) were recruited, and participants with periodontitis received periodontal treatment and 12 months' follow-up. Biomarkers for periodontal inflammation (gingival crevicular fluid interleukin-6, tumour necrosis factor-α, interleukin-1β, interferon-γ, matrix metalloproteinase-8, matrix metalloproteinase-9, adiponectin) and serum markers of inflammation and diabetes control (glycated haemoglobin, high sensitivity C-reactive protein, interleukin-6, tumour necrosis factor-α, interleukin-1β, interferon-γ, leptin, adiponectin) were measured. Structural equation modelling was used to evaluate periodontal treatment effects on oral and systemic inflammation.

Results: Periodontal treatment resulted in significant improvements in clinical status and reductions in gingival crevicular fluid biomarkers from baseline to month 12. Structural equation modelling identified that, at baseline, individuals with diabetes and periodontitis had significantly higher systemic inflammation than non-diabetic controls with periodontitis (Δ = 0.20, p = .002), with no significant differences between groups for oral inflammation. There was a greater reduction in systemic inflammation following periodontal treatment in individuals with diabetes and periodontitis compared to those with periodontitis but not diabetes (Δ = -0.25, p = .01).

Conclusions: Diabetes and periodontitis together appear to increase systemic inflammation, with evidence of reductions following periodontal treatment.

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Depositing User: Katrin Jaedicke


Item ID: 13266
Identification Number:
ISSN: 0303-6979
Official URL:

Users with ORCIDS

ORCID for Katrin Jaedicke: ORCID iD

Catalogue record

Date Deposited: 11 Mar 2021 17:06
Last Modified: 11 Mar 2021 17:06


Author: Katrin Jaedicke ORCID iD
Author: Philip M. Preshaw
Author: John J. Taylor
Author: Marco De Jager
Author: Jan Willem Bikker
Author: Wieke Selten
Author: Susan M. Bissett
Author: Kerry M. Whall
Author: Rachel van de Merwe
Author: Aisha Areibi
Author: Paiboon Jitprasertwong
Author: Rana Al-Shahwani
Author: Jolanta Weaver
Author: Roy Taylor
Author: Rebecca R. Wassall

University Divisions

Faculty of Health Sciences and Wellbeing > School of Nursing and Health Sciences


Sciences > Health Sciences

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