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Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

Insights into the Role of Matrix Metalloproteinases in Precancerous Conditions and in Colorectal Cancer

Pezeshkian, Zahra, Nobili, Stefania, Peyravian, Noshad, Shojaee, Bahador, Nazari, Haniye, Soleimani, Hiva, Asadzadeh-Aghdaei, Hamid, Ashrafian Bonab, Maziar, Nazemalhosseini-Mojarad, Ehsan and Mini, Enrico (2021) Insights into the Role of Matrix Metalloproteinases in Precancerous Conditions and in Colorectal Cancer. Cancers. ISSN 2072-6694

Item Type: Article


Colorectal cancer (CRC) is the third and second cancer for incidence and mortality worldwide, respectively, and is becoming prevalent in developing countries. Most CRCs derive from polyps, especially adenomatous polyps, which can gradually transform into CRC. The family of Matrix Metalloproteinases (MMPs) plays a critical role in the initiation and progression of CRC. Prominent MMPs, including MMP-1, MMP-2, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, MMP-14, and MMP-21, have been detected in CRC patients, and the expression of most of them correlates with a poor prognosis. Moreover, many studies have explored the inhibition of MMPs and targeted therapy for CRC, but there is not enough information about the role of MMPs in polyp malignancy. In this review, we discuss the role of MMPs in colorectal cancer and its pathogenesis.

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Depositing User: Maziar Ashrafian Bonab


Item ID: 14260
Identification Number:
ISSN: 2072-6694
Official URL:

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ORCID for Maziar Ashrafian Bonab: ORCID iD

Catalogue record

Date Deposited: 17 Dec 2021 15:16
Last Modified: 25 Jan 2022 08:47


Author: Maziar Ashrafian Bonab ORCID iD
Author: Zahra Pezeshkian
Author: Stefania Nobili
Author: Noshad Peyravian
Author: Bahador Shojaee
Author: Haniye Nazari
Author: Hiva Soleimani
Author: Hamid Asadzadeh-Aghdaei
Author: Ehsan Nazemalhosseini-Mojarad
Author: Enrico Mini

University Divisions

Faculty of Health Sciences and Wellbeing > School of Medicine


Sciences > Biomedical Sciences
Sciences > Health Sciences

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