Insights into the Role of Matrix Metalloproteinases in Precancerous Conditions and in Colorectal Cancer

Pezeshkian, Zahra, Nobili, Stefania, Peyravian, Noshad, Shojaee, Bahador, Nazari, Haniye, Soleimani, Hiva, Asadzadeh-Aghdaei, Hamid, Ashrafian Bonab, Maziar, Nazemalhosseini-Mojarad, Ehsan and Mini, Enrico (2021) Insights into the Role of Matrix Metalloproteinases in Precancerous Conditions and in Colorectal Cancer. Cancers. ISSN 2072-6694

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Abstract

Abstract
Colorectal cancer (CRC) is the third and second cancer for incidence and mortality worldwide, respectively, and is becoming prevalent in developing countries. Most CRCs derive from polyps, especially adenomatous polyps, which can gradually transform into CRC. The family of Matrix Metalloproteinases (MMPs) plays a critical role in the initiation and progression of CRC. Prominent MMPs, including MMP-1, MMP-2, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, MMP-14, and MMP-21, have been detected in CRC patients, and the expression of most of them correlates with a poor prognosis. Moreover, many studies have explored the inhibition of MMPs and targeted therapy for CRC, but there is not enough information about the role of MMPs in polyp malignancy. In this review, we discuss the role of MMPs in colorectal cancer and its pathogenesis.

Item Type: Article
Subjects: Sciences > Biomedical Sciences
Sciences > Health Sciences
Divisions: Faculty of Health Sciences and Wellbeing > School of Medicine
Depositing User: Maziar Ashrafian Bonab
Date Deposited: 17 Dec 2021 15:16
Last Modified: 17 Dec 2021 15:16
URI: http://sure.sunderland.ac.uk/id/eprint/14260
ORCID for Maziar Ashrafian Bonab: ORCID iD orcid.org/0000-0002-9833-7976

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