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Echinoderms provide missing link in the evolution of PrRP/sNPF-type neuropeptide signalling

Yañez-Guerra, Luis Alfonso, Zhong, Xingxing, Moghul, Ismail, Butts, Thomas, Zampronio, Cleidiane G, Jones, Alexandra M, Mirabeau, Olivier and Elphick, Maurice R (2020) Echinoderms provide missing link in the evolution of PrRP/sNPF-type neuropeptide signalling. eLife, 9. ISSN 2050-084X

Item Type: Article


Neuropeptide signalling systems comprising peptide ligands and cognate receptors are evolutionarily ancient regulators of physiology and behaviour. However, there are challenges associated with determination of orthology between neuropeptides in different taxa. Orthologs of vertebrate neuropeptide-Y (NPY) known as neuropeptide-F (NPF) have been identified in protostome invertebrates, whilst prolactin-releasing peptide (PrRP) and short neuropeptide-F (sNPF) have been identified as paralogs of NPY/NPF in vertebrates and protostomes, respectively. Here we investigated the occurrence of NPY/NPF/PrRP/sNPF-related signalling systems in a deuterostome invertebrate phylum – the Echinodermata. Analysis of transcriptome/genome sequence data revealed loss of NPY/NPF-type signalling, but orthologs of PrRP-type neuropeptides and sNPF/PrRP-type receptors were identified in echinoderms. Furthermore, experimental studies revealed that the PrRP-type neuropeptide pQDRSKAMQAERTGQLRRLNPRF-NH2 is a potent ligand for a sNPF/PrRP-type receptor in the starfish Asterias rubens. Our findings indicate that PrRP-type and sNPF-type signalling systems are orthologous and originated as a paralog of NPY/NPF-type signalling in Urbilateria.

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Depositing User: Leah Maughan


Item ID: 14338
Identification Number:
ISSN: 2050-084X
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Users with ORCIDS

ORCID for Thomas Butts: ORCID iD

Catalogue record

Date Deposited: 19 Jan 2022 11:32
Last Modified: 19 Jan 2022 11:32


Author: Thomas Butts ORCID iD
Author: Luis Alfonso Yañez-Guerra
Author: Xingxing Zhong
Author: Ismail Moghul
Author: Cleidiane G Zampronio
Author: Alexandra M Jones
Author: Olivier Mirabeau
Author: Maurice R Elphick

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Faculty of Health Sciences and Wellbeing > School of Medicine

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