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Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

Development of the cerebellum: simple steps to make a ‘little brain’

Butts, Thomas, Green, Mary J. and Wingate, Richard J. T. (2014) Development of the cerebellum: simple steps to make a ‘little brain’. Development, 141 (21). pp. 4031-4041. ISSN 0950-1991

Item Type: Article


The cerebellum is a pre-eminent model for the study of neurogenesis and circuit assembly. Increasing interest in the cerebellum as a participant in higher cognitive processes and as a locus for a range of disorders and diseases make this simple yet elusive structure an important model in a number of fields. In recent years, our understanding of some of the more familiar aspects of cerebellar growth, such as its territorial allocation and the origin of its various cell types, has undergone major recalibration. Furthermore, owing to its stereotyped circuitry across a range of species, insights from a variety of species have contributed to an increasingly rich picture of how this system develops. Here, we review these recent advances and explore three distinct aspects of cerebellar development – allocation of the cerebellar anlage, the significance of transit amplification and the generation of neuronal diversity – each defined by distinct regulatory mechanisms and each with special significance for health and disease.

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Depositing User: Leah Maughan


Item ID: 14343
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ISSN: 0950-1991
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ORCID for Thomas Butts: ORCID iD

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Date Deposited: 19 Jan 2022 10:59
Last Modified: 19 Jan 2022 10:59


Author: Thomas Butts ORCID iD
Author: Mary J. Green
Author: Richard J. T. Wingate

University Divisions

Faculty of Health Sciences and Wellbeing > School of Medicine

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