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Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

Citalopram inhibits platelet function independently of SERT-mediated 5-HT transport.

Roweth, Harvey G, Yan, Ruoling, Bedwani, Nader H, Chauhan, Alisha, Fowler, Nicole, Watson, Alice H, Malcor, Jean-Daniel, Sage, Stewart O and Jarvis, Gavin E. (2018) Citalopram inhibits platelet function independently of SERT-mediated 5-HT transport. Scientific reports, 8 (1). p. 3494. ISSN 2045-2322

Item Type: Article


Citalopram prevents serotonin (5-HT) uptake into platelets by blocking the serotonin reuptake transporter (SERT). Although some clinical data suggest that selective serotonin reuptake inhibitors (SSRIs) may affect haemostasis and thrombosis, these poorly-characterised effects are not well understood mechanistically and useful in vitro data is limited. We sought to determine whether the inhibitory effects of citalopram on platelets are mediated via its pharmacological inhibition of 5-HT transport. We quantified the inhibitory potency of (RS)-, (R)- and (S)-citalopram on platelet function. If SERT blockade is the primary mechanism for citalopram-mediated platelet inhibition, these potencies should show quantitative congruence with inhibition of 5-HT uptake. Our data show that citalopram inhibits platelet aggregation, adhesion and thromboxane production with no difference in potency between (R)- and (S)-isomers. By contrast, citalopram had a eudysmic ratio of approximately 17 (S > R) for SERT blockade. Furthermore, nanomolar concentrations of citalopram inhibited 5-HT uptake into platelets but had no effect on other platelet functions, which were inhibited by micromolar concentrations. Our data indicate that citalopram-induced inhibition of platelets in vitro is not mediated by blockade of 5-HT transport. This raises a new question for future investigation: by what mechanism(s) does citalopram inhibit platelets?

Roweth (2018) Citalopram inhibits platelet function independently of SERT-mediated 5-HT transport, SR.pdf - Published Version
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Depositing User: Gavin Jarvis


Item ID: 14415
Identification Number:
ISSN: 2045-2322
Official URL:

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ORCID for Gavin E. Jarvis: ORCID iD

Catalogue record

Date Deposited: 25 Jan 2022 12:41
Last Modified: 25 Jan 2022 12:45


Author: Gavin E. Jarvis ORCID iD
Author: Harvey G Roweth
Author: Ruoling Yan
Author: Nader H Bedwani
Author: Alisha Chauhan
Author: Nicole Fowler
Author: Alice H Watson
Author: Jean-Daniel Malcor
Author: Stewart O Sage

University Divisions

Faculty of Health Sciences and Wellbeing > School of Medicine


Sciences > Biomedical Sciences
Sciences > Pharmacy and Pharmacology

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