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Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

Dendrimers-Based Drug Delivery System: A Novel Approach in Addressing Parkinson’s Disease

Ordonio, Michaella B, Zaki, Randa Mohammed and Elkordy, Amal (2022) Dendrimers-Based Drug Delivery System: A Novel Approach in Addressing Parkinson’s Disease. Future Pharmacology, 2 (4). pp. 415-430.

Item Type: Article


Parkinson’s disease (PD) is a progressive neurodegenerative disease that is characterized
by the loss of dopamine. Since dopamine has trouble entering the blood–brain barrier, the utilization
of dendrimers and other nanomaterials is considered for conjugating the neurotransmitter and other
PD drugs. Dendrimers are three-dimensional, hyper-branched structures that are categorized into
several generations. Alpha-synuclein (ASN) is the protein involved in regulating dopaminergic
functions and is the main aggregate found inside Lewy bodies. Different types of dendrimers have
shown efficacy in disrupting the formation of unstable beta structures of ASN and fibrillation. The
conjugation of PD drugs into nanomaterials has elicited a prolonged duration of action and sustained
release of the drugs inside the BBB. The objectives of this study are to review the applications of a
dendrimer-based drug delivery system in addressing the root cause of Parkinson’s disease and to
emphasize the delivery of anti-Parkinson’s drugs such as rotigotine, pramipexole and dopamine
using routes of administration other than oral and intravenous.

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More Information

Depositing User: Amal Elkordy


Item ID: 15346
Identification Number:
Official URL:

Users with ORCIDS

ORCID for Amal Elkordy: ORCID iD

Catalogue record

Date Deposited: 17 Oct 2022 12:25
Last Modified: 17 Oct 2022 12:25


Author: Amal Elkordy ORCID iD
Author: Michaella B Ordonio
Author: Randa Mohammed Zaki

University Divisions

Faculty of Health Sciences and Wellbeing


Sciences > Pharmacy and Pharmacology

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