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Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

Magnesium Deficiency and Cardiometabolic Disease

Fritzen, Remi, Davies, Amy, Veenhuizen, Miriam, Campbell, Matthew, Pitt, Samantha, Ajjan, Ramzi A. and Stewart, Alan (2023) Magnesium Deficiency and Cardiometabolic Disease. Nutrients. pp. 1-19. ISSN 2072-6643

Item Type: Article


Magnesium (Mg2+) has many physiological functions within the body. These include important roles in maintaining cardiovascular functioning, where it contributes to the regulation of cardiac excitation–contraction coupling, endothelial functioning and haemostasis. The haemostatic roles of Mg2+ impact upon both the protein and cellular arms of coagulation. In this review, we examine how Mg2+ homeostasis is maintained within the body and highlight the various molecular roles attributed to Mg2+ in the cardiovascular system. In addition, we describe how nutritional and/or disease-associated magnesium deficiency, seen in some metabolic conditions, has the potential to influence cardiac and vascular outcomes. Finally, we also examine the potential for magnesium supplements to be employed in the prevention and treatment of cardiovascular disorders and in the management of cardiometabolic health.

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Uncontrolled Keywords: cardiovascular disease; magnesium; metal ion dyshomeostasis; nutrient deficiency; supplementation
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Depositing User: Matthew Campbell


Item ID: 16150
Identification Number:
ISSN: 2072-6643
Official URL:

Users with ORCIDS

ORCID for Matthew Campbell: ORCID iD

Catalogue record

Date Deposited: 24 May 2023 14:52
Last Modified: 11 Jul 2023 08:01


Author: Matthew Campbell ORCID iD
Author: Remi Fritzen
Author: Amy Davies
Author: Miriam Veenhuizen
Author: Samantha Pitt
Author: Ramzi A. Ajjan
Author: Alan Stewart

University Divisions

Faculty of Health Sciences and Wellbeing > School of Nursing and Health Sciences


Sciences > Health Sciences

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