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Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

Introduction about monoclonal antibodies

Elkordy, Amal and Carlile, Mark (2023) Introduction about monoclonal antibodies. In: Formulation of Monoclonal Antibody Therapies: From Lab to Market. Elsevier, pp. 1-38. ISBN 9780128233658

Item Type: Book Section


Therapeutic antibodies are the fastest growing class of biopharmaceutical in development. They are highly specific for target recognition and accordingly produce highly selective results after their administration. This chapter will cover a brief history of monoclonal antibodies (mAbs), their types, classification, structures, mechanism of actions, and clinical uses. In addition, this chapter will demonstrate the uniqueness of mAb characteristics leading to mAbs use for abroad range of targets, such as cancer, autoimmune disease, gastrointestinal, rheumatologically, hematological, dermatological, metabolic, cardiovascular, central nervous system, ophthalmic, dental and infectious diseases. The dominant areas of mAb therapeutic application are in oncology, immunology, and hematology. Also, the recent potential role of mAbs to treat coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), will be reported.

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Depositing User: Amal Elkordy


Item ID: 16197
ISBN: 9780128233658
Official URL:

Users with ORCIDS

ORCID for Amal Elkordy: ORCID iD

Catalogue record

Date Deposited: 01 Jun 2023 16:38
Last Modified: 01 Jun 2023 16:38


Author: Amal Elkordy ORCID iD
Author: Mark Carlile

University Divisions

Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences


Sciences > Pharmacy and Pharmacology

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