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Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

Route of monoclonal antibodies administration

Elkordy, Amal, Parveen, Amerah and Haj-Ahmad, Rita (2023) Route of monoclonal antibodies administration. In: Formulation of Monoclonal Antibody Therapies: From Lab to Market. Elsevier, pp. 209-258. ISBN 9780128233658

Item Type: Book Section


Monoclonal antibodies are biotherapeutics and one of the distinguished class of medicines which are being extensively used for the treatment of life-threatening diseases such as cancer and various infectious diseases. However, their formulations are challenging due to the complex structure of those protein-type therapeutics. mAbs are administered via injections either intravenous (IV), infusion route (need hospitalization) for high bioavailability and rapid action, or subcutaneous (SC) route (self-administration by patients using specialized SC injection pens), or intravitreally for very few mAbs. The injection route is not convenient for patients. Therefore, pharmaceutical industries and scientists are trying to find an alternative for this painful injectable route via noninvasive routes like oral, transdermal, and inhalation routes. Consequently, novel delivery systems have been explored to optimize the final products of mAbs—to be adaptable by these novel routes—through either formulations' technology or fabrication of the mAb delivery systems. Therefore, this chapter will discuss various novel approaches (e.g., drying technologies and particulate systems) to solve challenges in achieving effective mAb delivery via noninvasive routes (more specifically oral, transdermal, and inhalation routes of drug administrations).

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More Information

Depositing User: Amal Elkordy


Item ID: 16200
ISBN: 9780128233658
Official URL:

Users with ORCIDS

ORCID for Amal Elkordy: ORCID iD

Catalogue record

Date Deposited: 01 Jun 2023 16:39
Last Modified: 01 Jun 2023 16:39


Author: Amal Elkordy ORCID iD
Author: Amerah Parveen
Author: Rita Haj-Ahmad

University Divisions

Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences


Sciences > Pharmacy and Pharmacology

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