Monoclonal antibodies have proved to be a highly successful class of biopharmaceutical therapeutics. However, large-scale industrial manufacturing of these products is a complex process from the beginning steps of manufacturing, isolation, purification, final formulation, packaging, and storage. The packaging of monoclonal antibodies has an important role in providing stable and effective therapeutic antibodies. Therefore, the focus of this chapter will be on mAb packaging materials. There are three main packaging for monoclonal antibodies, glass vials, prefilled syringes, and autoinjectors. In this chapter, the structure, function, advantages, and disadvantages (in terms of stability and safety) of the three packaging types will be discussed.