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Phosphate starvation induces the sporulation killing factor of Bacillus subtilis.

Allenby, Nick, Watts, Carys A., Homuth, Georg, Prágai, Zoltán, Wipat, Anil, Ward, Alan C. and Harwood, Colin R. (2006) Phosphate starvation induces the sporulation killing factor of Bacillus subtilis. Journal of Bacteriology, 188 (14). pp. 5229-5303. ISSN 0021-9193

Item Type: Article


Bacillus subtilis produces and exports a peptide sporulation killing factor (SkfA) that induces lysis of sibling cells. skfA is part of the skf operon (skfA-H), which is responsible for immunity to SkfA, as well as for production and export of SkfA. Here we report that transcription of skfA is markedly induced when cells of B. subtilis are subjected to phosphate starvation. The role of PhoP in regulation of the skf operon was confirmed by in vitro gel shift assays, which showed that this operon is a new member of the PhoP regulon. A putative stem-loop structure in the skfA-skfB intergenic region is proposed to act as a stabilizer of an skfA-specific transcript.

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Depositing User: Nick Allenby


Item ID: 16428
Identification Number:
ISSN: 0021-9193
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ORCID for Nick Allenby: ORCID iD

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Date Deposited: 13 Sep 2023 13:58
Last Modified: 13 Sep 2023 13:58


Author: Nick Allenby ORCID iD
Author: Carys A. Watts
Author: Georg Homuth
Author: Zoltán Prágai
Author: Anil Wipat
Author: Alan C. Ward
Author: Colin R. Harwood

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Faculty of Health Sciences and Wellbeing


Sciences > Biomedical Sciences

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