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Genome-wide transcriptional analysis of the phosphate starvation stimulon of Bacillus subtilis.

Allenby, Nick, O'Connor, Nicola, Prágai, Zoltán, Ward, Alan C., Wipat, Anil and Harwood, Colin R. (2005) Genome-wide transcriptional analysis of the phosphate starvation stimulon of Bacillus subtilis. Journal of Bacteriology, 187 (23). pp. 8063-8080. ISSN 0021-9193

Item Type: Article


Bacillus subtilis responds to phosphate starvation stress by inducing the PhoP and SigB regulons. While the PhoP regulon provides a specific response to phosphate starvation stress, maximizing the acquisition of phosphate (Pi) from the environment and reducing the cellular requirement for this essential nutrient, the SigB regulon provides nonspecific resistance to stress by protecting essential cellular components, such as DNA and membranes. We have characterized the phosphate starvation stress response of B. subtilis at a genome-wide level using DNA macroarrays. A combination of outlier and cluster analyses identified putative new members of the PhoP regulon, namely, yfkN (2′,3′ cyclic nucleotide 2′-phosphodiesterase), yurI (RNase), yjdB (unknown), and vpr (extracellular serine protease). YurI is thought to be responsible for the nonspecific degradation of RNA, while the activity of YfkN on various nucleotide phosphates suggests that it could act on substrates liberated by YurI, which produces 3′ or 5′ phosphoribonucleotides. The putative new PhoP regulon members are either known or predicted to be secreted and are likely to be important for the recovery of inorganic phosphate from a variety of organic sources of phosphate in the environment.

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Depositing User: Nick Allenby


Item ID: 16429
Identification Number:
ISSN: 0021-9193
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ORCID for Nick Allenby: ORCID iD

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Date Deposited: 13 Sep 2023 13:08
Last Modified: 13 Sep 2023 13:08


Author: Nick Allenby ORCID iD
Author: Nicola O'Connor
Author: Zoltán Prágai
Author: Alan C. Ward
Author: Anil Wipat
Author: Colin R. Harwood

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Faculty of Health Sciences and Wellbeing


Sciences > Biomedical Sciences

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