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Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

The role of GCNT1 mediated O-glycosylation in aggressive prostate cancer

Hodgson, Kirsty, Orozco-Moreno, Margarita, Scott, Emma, Garnham, Rebecca, Livermore, Karen, Thomas, Huw D, Zhou, Yuhan, He, Jiepei, Bermudez, Abel, Marques, Fernando Jose Garcia, Bastian, Kayla, Hysenaj, Gerald, Goode, Emily Archer, Heer, Rakesh, Pitteri, Sharon, Wang, Ning, Elliott, David J and Munkley, Jennifer (2023) The role of GCNT1 mediated O-glycosylation in aggressive prostate cancer. Scientific Reports, 13 (1). p. 211. ISSN 2045-2322

Item Type: Article


Prostate cancer is the most common cancer in men and a major cause of cancer related deaths worldwide. Nearly all affected men develop resistance to current therapies and there is an urgent need to develop new treatments for advanced disease. Aberrant glycosylation is a common feature of cancer cells implicated in all of the hallmarks of cancer. A major driver of aberrant glycosylation in cancer is the altered expression of glycosylation enzymes. Here, we show that GCNT1, an enzyme that plays an essential role in the formation of core 2 branched O-glycans and is crucial to the final definition of O-glycan structure, is upregulated in aggressive prostate cancer. Using in vitro and in vivo models, we show GCNT1 promotes the growth of prostate tumours and can modify the glycome of prostate cancer cells, including upregulation of core 2 O-glycans and modifying the O-glycosylation of secreted glycoproteins. Furthermore, using RNA sequencing, we find upregulation of GCNT1 in prostate cancer cells can alter oncogenic gene expression pathways important in tumour growth and metastasis. Our study highlights the important role of aberrant O-glycosylation in prostate cancer progression and provides novel insights regarding the mechanisms involved.

Available under License Creative Commons Attribution.

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Depositing User: Rebecca Garnham


Item ID: 17650
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ISSN: 2045-2322
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Catalogue record

Date Deposited: 29 May 2024 10:31
Last Modified: 29 May 2024 10:45


Author: Kirsty Hodgson
Author: Margarita Orozco-Moreno
Author: Emma Scott
Author: Rebecca Garnham
Author: Karen Livermore
Author: Huw D Thomas
Author: Yuhan Zhou
Author: Jiepei He
Author: Abel Bermudez
Author: Fernando Jose Garcia Marques
Author: Kayla Bastian
Author: Gerald Hysenaj
Author: Emily Archer Goode
Author: Rakesh Heer
Author: Sharon Pitteri
Author: Ning Wang
Author: David J Elliott
Author: Jennifer Munkley

University Divisions

Faculty of Health Sciences and Wellbeing > School of Medicine


Sciences > Biomedical Sciences
Sciences > Health Sciences

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