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ST6GAL1: A key player in cancer

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Garnham, Rebecca, Scott, Emma, Livermore, Karen E and Munkley, Jennifer (2019) ST6GAL1: A key player in cancer. Oncology Letters, 18 (2). pp. 211-989. ISSN 1792-1074

Item Type: Article

Abstract

Aberrant glycosylation is a universal feature of cancer cells and there is now overwhelming evidence that glycans can modulate pathways intrinsic to tumour cell biology. Glycans are important in all of the cancer hallmarks and there is a renewed interest in the glycomic profiling of tumours to improve early diagnosis, determine patient prognosis and identify targets for therapeutic intervention. One of the most widely occurring cancer associated changes in glycosylation is abnormal sialylation which is often accompanied by changes in sialyltransferase activity. Several sialyltransferases are implicated in cancer, but in recent years ST6 β-galactoside α-2,6-sialyltransferase 1 (ST6GAL1) has become increasingly dominant in the literature. ST6GAL1 catalyses the addition of α2,6-linked sialic acids to terminal N-glycans and can modify glycoproteins and/or glycolipids. ST6GAL1 is upregulated in numerous types of cancer (including pancreatic, prostate, breast and ovarian cancer) and can promote growth, survival and metastasis. The present review discusses ST6GAL in relation to the hallmarks of cancer, and highlights its key role in multiple mechanisms intrinsic to tumour cell biology.

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Depositing User: Rebecca Garnham

Identifiers

Item ID: 17651
Identification Number: https://doi.org/10.3892/ol.2019.10458
ISSN: 1792-1074
URI: http://sure.sunderland.ac.uk/id/eprint/17651
Official URL: https://doi.org/10.3892/ol.2019.10458

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Catalogue record

Date Deposited: 29 May 2024 09:39
Last Modified: 29 May 2024 09:45

Contributors

Author: Rebecca Garnham
Author: Emma Scott
Author: Karen E Livermore
Author: Jennifer Munkley

University Divisions

Faculty of Health Sciences and Wellbeing > School of Medicine

Subjects

Sciences > Biomedical Sciences
Sciences > Health Sciences

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  • ST6GAL1: A key player in cancer. (deposited 29 May 2024 09:39) [Currently Displayed]