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Changes in mitochondrial function are pivotal in neurodegenerative and psychiatric disorders: How important is BDNF?

Markham, Anthony, Bains, R., Franklin, Paul and Spedding, M. (2014) Changes in mitochondrial function are pivotal in neurodegenerative and psychiatric disorders: How important is BDNF? British Journal of Pharmacology, 171 (8). pp. 2206-2229. ISSN 0007-1188

Item Type: Article

Abstract

The brain is at the very limit of its energy supply and has evolved specific means of adapting function to energy supply, of which mitochondria form a crucial link. Neurotrophic and inflammatory processes may not only have opposite effects on neuroplasticity, but also involve opposite effects on mitochondrial oxidative phosphorylation and glycolytic processes, respectively, modulated by stress and glucocorticoids, which also have marked effects on mood. Neurodegenerative processes show marked disorders in oxidative metabolism in key brain areas, sometimes decades before symptoms appear (Parkinson’s and Alzheimer’s diseases). We argue that brain-derived neurotrophic factor couples activity to changes in respiratory efficiency
and these effects may be opposed by inflammatory cytokines, a key factor in neurodegenerative processes.

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More Information

Depositing User: Hannah Dodd

Identifiers

Item ID: 5071
Identification Number: https://doi.org/10.1111/bph.12531
ISSN: 0007-1188
URI: http://sure.sunderland.ac.uk/id/eprint/5071
Official URL: http://onlinelibrary.wiley.com/doi/10.1111/bph.125...

Users with ORCIDS

Catalogue record

Date Deposited: 27 Aug 2014 09:16
Last Modified: 18 Dec 2019 15:37

Contributors

Author: Anthony Markham
Author: R. Bains
Author: Paul Franklin
Author: M. Spedding

University Divisions

Faculty of Health Sciences and Wellbeing
Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences

Subjects

Sciences > Biomedical Sciences
Sciences > Environment

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