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Comparative ochratoxin toxicity: a review of the available data

Heussner, A.H. and Bingle, Lewis (2015) Comparative ochratoxin toxicity: a review of the available data. Toxins, 7 (10). pp. 4253-4282. ISSN 2072-6651

Item Type: Article

Abstract

Ochratoxins are a group of mycotoxins produced by a variety of moulds. Ochratoxin A (OTA), the most prominent member of this toxin family, was first described by van der Merwe et al. in Nature in 1965. Dietary exposure to OTA represents a serious health issue and has been associated with several human and animal diseases including poultry ochratoxicosis, porcine nephropathy, human endemic nephropathies and urinary tract tumours in humans. More than 30 years ago, OTA was shown to be carcinogenic in rodents and since then extensive research has been performed in order to investigate its mode of action, however, this is still under debate. OTA is regarded as the most toxic family member, however, other ochratoxins or their metabolites and, in particular, ochratoxin mixtures or combinations with other mycotoxins may represent serious threats to human and animal health. This review summarises and evaluates current knowledge about the differential and comparative toxicity of the ochratoxin group.

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Depositing User: Paula Normington

Identifiers

Item ID: 5843
Identification Number: https://doi.org/10.3390/toxins7104253
ISSN: 2072-6651
URI: http://sure.sunderland.ac.uk/id/eprint/5843
Official URL: http://www.mdpi.com/2072-6651/7/10/4253

Users with ORCIDS

ORCID for Lewis Bingle: ORCID iD orcid.org/0000-0001-5168-5167

Catalogue record

Date Deposited: 10 Dec 2015 09:34
Last Modified: 18 Dec 2019 15:38